Precise replication of genetic material is essential to maintain genome stability. DNA
replication is a tightly regulated process that ensues faithful copies of DNA molecules to …

The WWOX gene was initially discovered as a putative tumor suppressor. More recently, its
association with multiple central nervous system (CNS) pathologies has been recognized …

There is a need to consider paternal contributions to autism spectrum disorder (ASD) more
strongly. Autism etiology is complex, and heritability is not explained by genetics alone …

Replicating the entire genome is one of the most complex tasks for all organisms. Research
carried out in the last few years has provided us with a clearer picture on how cells preserve …

Importance The biological processes that underlie the association of neighborhood
environment with chronic diseases, such as cancer, remain poorly understood. Objective To …

Some regions of the genome, notably common fragile sites (CFSs), are hypersensitive to
replication stress and often involved in the generation of gross chromosome rearrangements …

Metastatic cancer cells are frequently deficient in WWOX protein or express dysfunctional
WWOX (designated WWOXd). Here, we determined that functional WWOX-expressing …

Shortly after its discovery in 2000, WWOX was hailed as a tumor suppressor gene. In
subsequent years of research, this function was confirmed indisputably. Majority of tumors …

Purpose Bladder cancer is the most common malignancy of the urinary tract and one of the
most prevalent cancers worldwide. It represents a spectrum of diseases, from recurrent non …

Common fragile sites (CFSs) are particularly vulnerable regions of the genome that become
visible as breaks, gaps, or constrictions on metaphase chromosomes when cells are under …