Programmed cell death protein-1 (PD-1), also called CD279, is coded by the PDCD1 gene
and is constitutively expressed on the surface of immune cells. As a receptor and immune …

Breast cancer (BC), one of the most widespread and devastating diseases affecting women
worldwide, presents a significant public health challenge. This review explores the emerging …

Immunotherapy aims to stimulate the immune system to inhibit tumor growth or prevent
metastases. Tumor cells primarily employ altered expression of human leukocyte antigen …

Cancer immunotherapy has emerged as a promising strategy for the treatment of cancer,
with the tumor microenvironment (TME) playing a pivotal role in modulating the immune …

Despite advances in cancer treatment, hepatocellular carcinoma (HCC), the most common
form of liver cancer, remains a major public health problem worldwide. The immune …

Background The mechanisms whereby CYFIP2 acts in tumor development and drives
immune infiltration have been poorly explored. Thus, this study aimed to identifying the role …

Primary cutaneous melanoma is the most lethal of all skin neoplasms and its incidence is
increasing. Clinical management of advanced melanoma in the last decade has been …

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived
from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal …

Simple Summary This is a thorough literature review of SHP2 inhibition, its application in
cancer therapy and current uses as an immune modulator. The aberrant activation of SHP2 …

Simple Summary Glioblastoma (GBM) is an aggressive brain tumor with limited treatment
success. Despite efforts, the prognosis remains poor, impacting patients' quality of life …