Potassium-competitive acid blockade: a new therapeutic strategy in acid-related diseases
K Andersson, E Carlsson - Pharmacology & therapeutics, 2005 - Elsevier
Current therapies to treat gastroesophageal reflux disease (GERD), peptic ulcer disease
(PUD), and other acid-related diseases either prevent stimulation of the parietal cell (H2 …
(PUD), and other acid-related diseases either prevent stimulation of the parietal cell (H2 …
Cholecystokinin antagonists: pharmacological and therapeutic potential
R Herranz - Medicinal research reviews, 2003 - Wiley Online Library
Cholecystokinin (CCK) is a regulatory peptide hormone, predominantly found in the
gastrointestinal tract, and a neurotransmitter present throughout the nervous system. In the …
gastrointestinal tract, and a neurotransmitter present throughout the nervous system. In the …
Acid suppression therapy: where do we go from here?
C Scarpignato, I Pelosini, F Di Mario - Digestive Diseases, 2006 - karger.com
The dramatic success of pharmacological acid suppression in healing peptic ulcers and
managing patients with gastroesophageal reflux disease (GERD) has been reflected in the …
managing patients with gastroesophageal reflux disease (GERD) has been reflected in the …
Gastrin: old hormone, new functions
G Dockray, R Dimaline, A Varro - Pflügers Archiv, 2005 - Springer
It is exactly a century since the gastric hormone gastrin was first described as a blood-borne
regulator of gastric acid secretion. The identities of the main active forms of the hormone (the …
regulator of gastric acid secretion. The identities of the main active forms of the hormone (the …
Role of CCK/gastrin receptors in gastrointestinal/metabolic diseases and results of human studies using gastrin/CCK receptor agonists/antagonists in these diseases
In this paper, the estabished and possible roles of CCK1 and CCK2 receptors in
gastrointestinal (GI) and metabolic diseases are reviewed and available results from human …
gastrointestinal (GI) and metabolic diseases are reviewed and available results from human …
Novel approaches to the pharmacological blockade of gastric acid secretion
ME Parsons, DJ Keeling - Expert opinion on investigational drugs, 2005 - Taylor & Francis
Research into new methods of controlling acid secretion is driven by existing medical needs
in gastro-oesophageal reflux disease treatment. Histamine receptor subtype 3 agonists offer …
in gastro-oesophageal reflux disease treatment. Histamine receptor subtype 3 agonists offer …
Involvement of cholecystokinin/gastrin‐related peptides and their receptors in clinical gastrointestinal disorders
RT Jensen - Pharmacology & toxicology, 2002 - Wiley Online Library
In this paper the possible roles of cholecystokinin (CCK), gastrin, or gastrin‐related peptides
and their receptors in human gastrointestinal diseases are reviewed. For CCK/CCKA …
and their receptors in human gastrointestinal diseases are reviewed. For CCK/CCKA …
A comparative time‐dependent study of hematology, serum gastrin concentrations, and gastroscopic assessment of meloxicam‐induced gastric ulceration in dogs
Background Diagnosis of gastric ulcers by methods other than gastroscopy in dogs has
been problematic for many years and biomarkers such as serum gastrin (SG) concentrations …
been problematic for many years and biomarkers such as serum gastrin (SG) concentrations …
The role of gastrin in ulcer pathogenesis
KEL McColl, D Gillen, E El-Omar - Best Practice & Research Clinical …, 2000 - Elsevier
Duodenal ulcer patients are characterized by an antrum-predominant, body-sparing, non-
atrophicHelicobacter pylori (H. pylori) gastritis, which results in increased gastrin release …
atrophicHelicobacter pylori (H. pylori) gastritis, which results in increased gastrin release …
Optimization of 1,3,4-Benzotriazepine-Based CCK2 Antagonists to Obtain Potent, Orally Active Inhibitors of Gastrin-Mediated Gastric Acid Secretion
IM McDonald, JW Black, IM Buck… - Journal of medicinal …, 2007 - ACS Publications
Starting from a novel, achiral 1, 3, 4-benzotriazepine-based CCK2 receptor antagonist, a
process of optimization has afforded further compounds of this type that maintain the …
process of optimization has afforded further compounds of this type that maintain the …