Current therapies to treat gastroesophageal reflux disease (GERD), peptic ulcer disease
(PUD), and other acid-related diseases either prevent stimulation of the parietal cell (H2 …

Cholecystokinin (CCK) is a regulatory peptide hormone, predominantly found in the
gastrointestinal tract, and a neurotransmitter present throughout the nervous system. In the …

The dramatic success of pharmacological acid suppression in healing peptic ulcers and
managing patients with gastroesophageal reflux disease (GERD) has been reflected in the …

It is exactly a century since the gastric hormone gastrin was first described as a blood-borne
regulator of gastric acid secretion. The identities of the main active forms of the hormone (the …

In this paper, the estabished and possible roles of CCK1 and CCK2 receptors in
gastrointestinal (GI) and metabolic diseases are reviewed and available results from human …

Research into new methods of controlling acid secretion is driven by existing medical needs
in gastro-oesophageal reflux disease treatment. Histamine receptor subtype 3 agonists offer …

In this paper the possible roles of cholecystokinin (CCK), gastrin, or gastrin‐related peptides
and their receptors in human gastrointestinal diseases are reviewed. For CCK/CCKA …

Background Diagnosis of gastric ulcers by methods other than gastroscopy in dogs has
been problematic for many years and biomarkers such as serum gastrin (SG) concentrations …

Duodenal ulcer patients are characterized by an antrum-predominant, body-sparing, non-
atrophicHelicobacter pylori (H. pylori) gastritis, which results in increased gastrin release …

Starting from a novel, achiral 1, 3, 4-benzotriazepine-based CCK2 receptor antagonist, a
process of optimization has afforded further compounds of this type that maintain the …