Oxycodone, a semisynthetic derivative of naturally occurring thebaine, an opioid alkaloid,
has been available for more than 100 years. Although thebaine cannot be used …

Pain is an unpleasant sensory and emotional experience that affects every aspect of a
patient's life and which may be treated through different pharmacological and non …

Background and Purpose Mitragynine, the major alkaloid in Mitragyna speciosa (kratom), is
a partial agonist at the μ opioid receptor. CYP3A‐dependent oxidation of mitragynine yields …

The aim of this study was to assess the patterns and trends of pharmacological treatment for
outpatients with postherpetic neuralgia (PHN) in China in the period 2015–2019 …

Patients suffering from chronic pain may respond differently to analgesic medications. For
some, pain relief is insufficient, while others experience side effects. Although …

Purpose Oxycodone-acetaminophen is a synergic combination of semisynthetic opioid
agonis and analgesic/antipyretic agent, which improves analgesic efficacy. This …

Oxycodone is one of the most commonly used opioids to treat moderate to severe pain. It is
metabolized mainly by CYP3A4 and CYP2D6, while only a small fraction of the dose is …

vi such as ion channels, membrane transporters, receptors, and enzymes are playing
increasingly essential roles in drug design and pharmacogenomics studies (see Chapters 6 …

Introduction The polymorphism of the gene coding mu-opioid receptor (OPRM1) is one of
the factors contributing to the variability in the response to opioid analgesics in children. The …

Background: Variability in the pharmacokinetics and pharmacodynamics of oxycodone in
children undergoing surgery could be due to genetic polymorphisms. Materials & methods …