New generations of synthetic biomaterials are being developed at a rapid pace for use as
three-dimensional extracellular microenvironments to mimic the regulatory characteristics of …

The extracellular matrix (ECM) is critical for all aspects of vascular biology. In concert with
supporting cells, endothelial cells (ECs) assemble a laminin-rich basement membrane …

During angiogenesis, endothelial cells (ECs) from intact blood vessels quickly infiltrate
avascular regions via vascular sprouting. This process is fundamental to many normal and …

Cell migration is a universal process involving different morphologies and mechanisms in
different cell types and tissue environments. Prespecified cell-type-specific patterns of cell …

Filopodia,“the fingers that do the walking,” have been identified on endothelial cells at the tip
of sprouting vessels for half a century, but the key role of the tip cell in vessel branching has …

The extracellular matrix is a complex, dynamic and critical component of all tissues. It
functions as a scaffold for tissue morphogenesis, provides cues for cell proliferation and …

The extracellular matrix (ECM) plays a crucial role in all parts of the eye, from maintaining
clarity and hydration of the cornea and vitreous to regulating angiogenesis, intraocular …

Tumors can undergo long periods of dormancy, with cancer cells entering a largely
quiescent, nonproliferative state before reactivation and outgrowth. To understand the role of …

Rationale: The miR-143/145 cluster is highly expressed in smooth muscle cells (SMCs),
where it regulates phenotypic switch and vascular homeostasis. Whether it plays a role in …

The formation of epithelial tubes is crucial for the proper development of many different
tissues and organs, and occurs by means of a variety of different mechanisms …