Bivalent chromatin is defined by the co-occurrence of otherwise opposing H3K4me3 and
H3K27me3 modifications and is typically located at unmethylated promoters of lowly …

Highlights•Various partner proteins associate sub-stoichiometrically, impacting PRC2
activities.•Distinctive PRC2 subcomplexes form in tissue-specific and spatiotemporal …

RNA has been implicated in the recruitment of chromatin modifiers, and previous studies
have provided evidence in favor and against this idea. RNase treatment of chromatin is …

Summary Polycomb repressive complex 1 (PRC1) is a key transcriptional regulator in
development via modulating chromatin structure and catalyzing histone H2A ubiquitination …

Abstract Polycomb repressive complex 2 (PRC2) interacts with RNA in cells, but there is no
consensus on how RNA regulates PRC2 canonical functions, including chromatin …

Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) are transcriptional repressor
complexes that play a fundamental role in epigenomic regulation and the cell-fate decision; …

Epigenetic factors are crucial for ensuring proper chromatin dynamics during the initial
stages of embryo development. Among these factors, the Polycomb group (PcG) of proteins …

Loss or downregulation of major histocompatibility complex class I (MHC‐I) contributes to
tumor immune evasion. We previously demonstrated that angiopoietin‐like protein 2 …

Background Bivalent chromatin is an exemplar of epigenetic plasticity. This co-occurrence of
active-associated H3K4me3 and inactive-associated H3K27me3 histone modifications on …

The development of multicellular organisms depends on spatiotemporally controlled
differentiation of numerous cell types and their maintenance. To generate such diversity …