The growing clinical success of hematopoietic stem/progenitor cell (HSPC) gene therapy
(GT) relies on the development of viral vectors as portable" Trojan horses" for safe and …

Developmental hematopoiesis consists of multiple, partially overlapping hematopoietic
waves that generate the differentiated blood cells required for embryonic development while …

The human bone marrow (BM) niche sustains hematopoiesis throughout life. We present a
method for generating complex BM-like organoids (BMOs) from human induced pluripotent …

Hematopoietic progenitors are enriched in the endocardial cushion and contribute, in a
Nkx2-5-dependent manner, to tissue macrophages required for the remodeling of cardiac …

The developmental origin of blood-forming hematopoietic stem cells (HSCs) is a
longstanding question. Here, our non-invasive genetic lineage tracing in mouse embryos …

During embryonic development, blood cells emerge from specialized endothelial cells,
named haemogenic endothelial cells (HECs). As HECs are rare and only transiently found …

Recent findings suggest that Hematopoietic Stem Cells (HSC) and progenitors arise
simultaneously and independently of each other already in the embryonic aorta-gonad …

Several decades have passed since the generation of the first embryonic stem cell (ESC)
lines both in mice and in humans. Since then, stem cell biologists have tried to understand …

Hematopoietic stem cells (HSCs) give rise to nearly all blood cell types and play a central
role in blood cell production in adulthood. For many years it was assumed that these roles …

Hematopoietic stem cells (HSCs) and multipotent progenitor cells (MPPs) arise in
successive waves during ontogeny, and their properties change significantly throughout life …