[HTML][HTML] Inhibition of spores to prevent the recurrence of Clostridioides difficile infection-A possibility or an improbability?

CW Chiu, PJ Tsai, CC Lee, WC Ko, YP Hung - Journal of Microbiology …, 2021 - Elsevier
Clostridioides difficile is one of the most common nosocomial gastrointestinal pathogens,
and recurrence is a problematic issue because approximately 20–30% of patients …

The burden of Clostridioides difficile infections in South-East Asia and the Western Pacific: A narrative review

FJ Angulo, C Ghia, MA Fletcher, E Ozbilgili, G Morales - Anaerobe, 2024 - Elsevier
Abstract Background Clostridioides difficile (formerly Clostridium difficile) is well-
documented in Europe and North America to be a common cause of healthcare-associated …

The Role of Toll-Like Receptor-2 in Clostridioides difficile Infection: Evidence From a Mouse Model and Clinical Patients

YH Lai, BY Tsai, CY Hsu, YH Chen, PH Chou… - Frontiers in …, 2021 - frontiersin.org
Background Clostridioides difficile is the leading cause of nosocomial infectious diarrhea.
Toll-like receptors (TLRs) are the major components of innate immunity that sense …

Clinical significance of toxigenic Clostridioides difficile growth in stool cultures during the era of nonculture methods for the diagnosis of C. difficile infection

CC Lee, JC Lee, CW Chiu, PJ Tsai, WC Ko… - Microbiology …, 2021 - Am Soc Microbiol
The importance of the detection of relevant toxins or toxin genes to diagnose Clostridioides
difficile infection (CDI) or the prediction of clinical outcomes of CDI has been emphasized in …

Neutrophil Ratio of White Blood Cells as a Prognostic Predictor of Clostridioides difficile Infection

CC Lee, JC Lee, CW Chiu, PJ Tsai… - Journal of …, 2022 - Taylor & Francis
Introduction A leukocyte count≥ 15,000 cells/mL and serum creatinine of> 1.5 mg/dL have
been reported as two important predictors of severe CDI. However, the association of the …

[HTML][HTML] The emergence of Clostridioides difficile PCR ribotype 127 at a hospital in northeastern Taiwan

BY Tsai, CC Chien, SH Huang, JY Zheng… - Journal of Microbiology …, 2022 - Elsevier
Background Several studies have highlighted the incidence of Clostridioides difficile
infections (CDIs) in Taiwan and certain ribotypes have been related to severe clinical …

Clostridium butyricum therapy for mild-moderate Clostridioides difficile infection and the impact of diabetes mellitus

JC Lee, CW Chiu, PJ Tsai, CC Lee… - … of Microbiota, Food …, 2022 - jstage.jst.go.jp
The therapeutic effect of Clostridium butyricum for adults with Clostridioides difficile infection
(CDI) was investigated. A retrospective study was conducted in medical wards of Tainan …

Impacts of Corticosteroid Therapy at Acute Stage of Hospital-Onset Clostridioides difficile Infections

CC Lee, JC Lee, CW Chiu, PJ Tsai… - Infection and Drug …, 2022 - Taylor & Francis
Introduction The influence of corticosteroid therapy before or after the onset of Clostridioides
difficile infections (CDIs) on the clinical outcomes of adults with hospital-onset CDIs was …

Association of Single Nucleotide Polymorphisms in Nucleotide-Binding Domain Leucine-Rich Repeat Protein 1 with Clostridioides difficile Colonization or Infection

BY Tsai, PJ Tsai, CC Lee, CW Chiu, YH Lai… - Infection and Drug …, 2023 - Taylor & Francis
Introduction Nucleotide-binding domain leucine-rich repeat protein (NLRP) is critical in the
inflammasome-activation pathway, which is important for host survival and the clearance of …

[HTML][HTML] Reappraisal of the clinical role of metronidazole therapy for Clostridioides difficile infection in Taiwan: A multicenter prospective study

JC Lee, CC Lee, CW Chiu, PJ Tsai, PR Hsueh… - Journal of the Formosan …, 2022 - Elsevier
Background/Purpose Although metronidazole is not recommended to treat Clostridioides
difficile infection (CDI) in Western countries, it was still to be recommended for the treatment …