The epigenetic modifications of histones are versatile marks that are intimately connected to
development and disease pathogenesis including human cancers. In this review, we will …

Numerous biological processes are concurrently and coordinately active in every living cell.
Each of them encompasses synthetic, catalytic and regulatory functions that are, almost …

Here we report the identification and verification of a β-hydroxybutyrate-derived protein
modification, lysine β-hydroxybutyrylation (Kbhb), as a new type of histone mark. Histone …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Alterations in the epigenome and metabolism both affect molecular rewiring in cancer cells
and facilitate cancer development and progression. However, recent evidence suggests the …

Background Many metabolites serve as important signalling molecules to adjust cellular
activities and functions based on nutrient availability. Links between acetyl-CoA metabolism …

As the main protein components of chromatin, histones play central roles in gene regulation
as spools of winding DNA. Histones are subject to various modifications, including …

Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …

Recognition of pathogens by innate and adaptive immune cells instructs rapid alterations of
cellular processes to promote effective resolution of infection. To accommodate increased …

Metabolic regulation of histone marks is associated with diverse biological processes
through dynamically modulating chromatin structure and functions. Here we report the …