Acute-on-chronic liver failure clinical guidelines
In patients with cirrhosis and chronic liver disease, acute-on-chronic liver failure is emerging
as a major cause of mortality. These guidelines indicate the preferred approach to the …
as a major cause of mortality. These guidelines indicate the preferred approach to the …
[HTML][HTML] Immunological mechanisms and therapeutic targets of fatty liver diseases
Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …
[HTML][HTML] Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure
Intrahepatic neutrophil infiltration has been implicated in severe alcoholic hepatitis (SAH)
pathogenesis; however, the mechanism underlying neutrophil-induced injury in SAH …
pathogenesis; however, the mechanism underlying neutrophil-induced injury in SAH …
The knowns and unknowns of treatment for alcoholic hepatitis
TS Sehrawat, M Liu, VH Shah - The lancet Gastroenterology & …, 2020 - thelancet.com
Alcoholic hepatitis is an acute, inflammatory liver disease associated with high morbidity and
mortality both in the short term and long term. Alcoholic hepatitis often arises in patients with …
mortality both in the short term and long term. Alcoholic hepatitis often arises in patients with …
Role of extracellular vesicles in liver diseases and their therapeutic potential
E Kostallari, S Valainathan, L Biquard, VH Shah… - Advanced drug delivery …, 2021 - Elsevier
More than eight hundred million people worldwide have chronic liver disease, with two
million deaths per year. Recurring liver injury results in fibrogenesis, progressing towards …
million deaths per year. Recurring liver injury results in fibrogenesis, progressing towards …
[HTML][HTML] Extracellular vesicles as tools and targets in therapy for diseases
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the
extracellular space. They exhibit diverse sizes, contents, and surface markers and are …
extracellular space. They exhibit diverse sizes, contents, and surface markers and are …
Circulating extracellular vesicles carrying sphingolipid cargo for the diagnosis and dynamic risk profiling of alcoholic hepatitis
Background and Aims Alcoholic hepatitis (AH) is diagnosed by clinical criteria, although
several objective scores facilitate risk stratification. Extracellular vesicles (EVs) have …
several objective scores facilitate risk stratification. Extracellular vesicles (EVs) have …
[HTML][HTML] Programmed cell death in alcohol-associated liver disease
T Miyata, LE Nagy - Clinical and Molecular Hepatology, 2020 - ncbi.nlm.nih.gov
Alcohol-associated liver disease (ALD), which ranges from mild disease to alcohol-
associated hepatitis and cirrhosis, is the most prevalent type of chronic liver disease and a …
associated hepatitis and cirrhosis, is the most prevalent type of chronic liver disease and a …
[HTML][HTML] Aryl hydrocarbon receptor deficiency in intestinal epithelial cells aggravates alcohol-related liver disease
M Qian, J Liu, D Zhao, P Cai, C Pan, W Jia… - Cellular and molecular …, 2022 - Elsevier
Background & Aims The ligand-activated transcription factor, aryl hydrocarbon receptor
(AHR) can sense xenobiotics, dietary, microbial, and metabolic cues. Roles of Ahr in …
(AHR) can sense xenobiotics, dietary, microbial, and metabolic cues. Roles of Ahr in …
Research methodologies to address clinical unmet needs and challenges in alcohol‐associated liver disease
Alcohol‐associated liver disease (ALD) is emerging worldwide as the leading cause of liver‐
related morbidity, mortality, and indication for liver transplantation. The ALD Special Interest …
related morbidity, mortality, and indication for liver transplantation. The ALD Special Interest …