Macrophages are key inflammatory immune cells that display dynamic phenotypes and
functions in response to their local microenvironment. Major advances have occurred in …

The pineal gland-derived indoleamine hormone, melatonin, regulates multiple cellular
processes, ranging from chronobiology, proliferation, apoptosis, and oxidative damage to …

Epigenetic modulation can affect the characteristics of cancers. Because it is likely to
manipulate epigenetic genes, they can be considered as potential targets for cancer …

DNA methylation is a mammalian epigenetic mark that participates to define where and
when genes are expressed, both in normal cells and in the context of diseases. Like other …

Simple Summary Despite advances in cancer treatment, difficult-to-treat tumor subtypes
remain a challenge. New multidisciplinary approaches can help overcome current obstacles …

Unveiling the secrets of genome's flexibility does not only foster new research in the field,
but also gives rise to the exploration and development of novel epigenetic-based therapies …

Epigenetic modifications are heritable yet reversible, essential for normal physiological
functions and biological development. Aberrant epigenetic modifications, including DNA …

Cancer is a disease of uncontrolled cell growth and a major cause of death worldwide. Many
molecular events characterize tumor initiation and progression. Global gene expression …

Multiple myeloma (MM) is a malignant hematological disease. The disease is characterized
by the clonal proliferation of malignant plasma cells in the bone marrow. MM accounts for …

An improvement in pancreatic cancer treatment represents an urgent medical goal. Late
diagnosis and high intrinsic resistance to conventional chemotherapy has led to a dismal …