All cancers have multiple mutations that can largely be grouped into certain classes
depending on the function of the gene in which they lie and these include oncogenic …

Advances in engineered recombinant nuclease have provided facile and reliable methods
for genome editing. Especially with the development of the CRISPR (clustered regularly …

Hepatocellular carcinoma (HCC) remains a major health problem worldwide with a
continuous increasing prevalence. Despite the introduction of targeted therapies like the …

The study of the epigenetic regulation of gene function has reached pivotal importance in life
sciences in the last decades. The mechanisms and effects of processes such as DNA …

Sulforaphane (SFN) may hinder carcinogenesis by altering epigenetic events in the cells;
however, its molecular mechanisms are unclear. The present study investigates the role of …

Huntington's disease (HD) is a devastating and fatal monogenic neurodegenerative disorder
characterized by progressive loss of selective neurons in the brain and is caused by an …

Tumour heterogeneity poses a distinct obstacle to therapeutic intervention. While the
initiation of tumours across various physiological systems is frequently associated with …

Highlights•Summary of the synergistic approaches so far demonstrated with bromodomain
inhibitors in cancer and their clinical implications.•Combination therapies with BET inhibition …

Among the inherited causes of intellectual disability and autism, Fragile X syndrome (FXS) is
the most frequent form, for which there is currently no cure. In most FXS patients, the FMR1 …

Cancer heterogeneity and drug resistance remain pivotal obstacles in effective cancer
treatment and management. One major contributor to these challenges is epigenetic …