Translating cancer epigenomics into the clinic: focus on lung cancer
J Mari-Alexandre, A Diaz-Lagares, M Villalba… - Translational …, 2017 - Elsevier
Epigenetic deregulation is increasingly being recognized as a hallmark of cancer. Recent
studies have identified many new epigenetic biomarkers, some of which are being …
studies have identified many new epigenetic biomarkers, some of which are being …
[HTML][HTML] Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors
W Fried, M Tyagi, L Minakhin, G Chandramouly… - Nature …, 2024 - nature.com
The DNA damage response (DDR) protein DNA Polymerase θ (Polθ) is synthetic lethal with
homologous recombination (HR) factors and is therefore a promising drug target in …
homologous recombination (HR) factors and is therefore a promising drug target in …
A summary of the biological processes, disease-associated changes, and clinical applications of DNA methylation
GB Andersen, J Tost - DNA Methylation Protocols, 2018 - Springer
DNA methylation at cytosines followed by guanines, CpGs, forms one of the multiple layers
of epigenetic mechanisms controlling and modulating gene expression through chromatin …
of epigenetic mechanisms controlling and modulating gene expression through chromatin …
[HTML][HTML] Clinical and mechanistic implications of R-loops in human leukemias
Genetic mutations or environmental agents are major contributors to leukemia and are
associated with genomic instability. R-loops are three-stranded nucleic acid structures …
associated with genomic instability. R-loops are three-stranded nucleic acid structures …
Targeting epigenetic regulators for cancer therapy: modulation of bromodomain proteins, methyltransferases, demethylases, and microRNAs
KA Gelato, D Adler, M Ocker… - Expert opinion on …, 2016 - Taylor & Francis
ABSTRACT Introduction: Histone deacetylases (HDACs) and DNA methyltransferases
(DNMTs) were the first epigenetic targets to be successfully addressed for cancer treatment …
(DNMTs) were the first epigenetic targets to be successfully addressed for cancer treatment …
[HTML][HTML] Differential analysis of RNA methylation regulators in gastric cancer based on TCGA data set and construction of a prognostic model
J Li, Z Zuo, S Lai, Z Zheng, B Liu, Y Wei… - Journal of …, 2021 - ncbi.nlm.nih.gov
Background Methylation is one of the common forms of RNA modification, which mainly
include N6-methyladenosine (m6A), C5-methylcytidine (m5C), and N1-methyladenosine …
include N6-methyladenosine (m6A), C5-methylcytidine (m5C), and N1-methyladenosine …
EHMT2 epigenetically suppresses Wnt signaling and is a potential target in embryonal rhabdomyosarcoma
Wnt signaling is downregulated in embryonal rhabdomyosarcoma (ERMS) and contributes
to the block of differentiation. Epigenetic mechanisms leading to its suppression are …
to the block of differentiation. Epigenetic mechanisms leading to its suppression are …
Writers, readers, and erasers of epigenetic marks
TB Nicholson, N Veland, T Chen - Epigenetic cancer therapy, 2015 - Elsevier
Changes in gene expression and activity underlie the formation of cancerous tumors.
Historically, alterations (deletions, point mutations, translocations, etc.) in the DNA genome …
Historically, alterations (deletions, point mutations, translocations, etc.) in the DNA genome …
[HTML][HTML] Prognostic biomarker GSTK1 in head and neck squamous cell carcinoma and its correlation with immune infiltration and DNA methylation
Y Feng, YH Zhou, J Zhao, XL Su, NX Chen… - Frontiers in …, 2023 - frontiersin.org
Background: Glutathione S-transferase kappa 1 (GSTK1) is critical in sarcoma and breast
cancer (BRCA) development. However, the clinical significance of GSTK1 in head and neck …
cancer (BRCA) development. However, the clinical significance of GSTK1 in head and neck …
Epigenomics-guided drug development: recent advances in solving the cancer treatment “jigsaw puzzle”
K Dzobo - Omics: a journal of integrative biology, 2019 - liebertpub.com
The human epigenome plays a key role in determining cellular identity and eventually
function. Drug discovery undertakings have focused mainly on the role of genomics in …
function. Drug discovery undertakings have focused mainly on the role of genomics in …