The emergence of new viruses and resistant strains of pathogenic microorganisms has
become a powerful stimulus in the search for new drugs. Nucleosides are a promising class …

Despite intensive research extending back to the 1930s, when the first synthetic antimalarial
drugs made their appearance, the repertoire of clinically licensed formulations remains very …

Tuberculosis (TB) is one of three major infectious diseases, and the control of TB is
becoming more difficult because of the emergence of multidrug-resistant and extensively …

Malaria remains a globally prevalent infectious disease that leads to significant morbidity
and mortality. While there are a number of drugs approved for its treatment, drug resistance …

The importance of pyrimidines lies in the fact that they are structural components of a broad
spectrum of key molecules that participate in diverse cellular functions, such as synthesis of …

Malaria is a leading cause of morbidity and mortality in the tropics. Chemotherapeutic and
vector control strategies have been applied for more than a century but have not been …

While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are
thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that …

Genome-wide analysis of transcription in the malaria parasite Plasmodium falciparum has
revealed robust variation in steady-state mRNA abundance throughout the 48-h …

For over a century, heme metabolism has been recognized to play a central role during
intraerythrocytic infection by Plasmodium parasites, the causative agent of malaria …

Neuropathies associated with nutritional deficiencies are routinely encountered by the
practicing neurologist. Although these neuropathies assume different patterns, most are …