[HTML][HTML] Metabolic interactions between Toxoplasma gondii and its host
M Blume, F Seeber - F1000Research, 2018 - ncbi.nlm.nih.gov
Toxoplasma gondii is an obligate intracellular parasite belonging to the phylum
Apicomplexa that infects all warm-blooded animals, including humans. T. gondii can …
Apicomplexa that infects all warm-blooded animals, including humans. T. gondii can …
Utility of the biosynthetic folate pathway for targets in antimicrobial discovery
CR Bourne - Antibiotics, 2014 - mdpi.com
The need for new antimicrobials is great in face of a growing pool of resistant pathogenic
organisms. This review will address the potential for antimicrobial therapy based on …
organisms. This review will address the potential for antimicrobial therapy based on …
Purine Salvage Pathways in the Intraerythrocytic Malaria Parasite Plasmodium falciparum
MJ Downie, K Kirk, CB Mamoun - Eukaryotic cell, 2008 - Am Soc Microbiol
Malaria is caused by protozoan parasites of the genus Plasmodium. Five species of
Plasmodium cause infection in humans, with the majority of lethal cases caused by …
Plasmodium cause infection in humans, with the majority of lethal cases caused by …
Drug-induced megaloblastic anemia
CS Hesdorffer, DL Longo - New England Journal of Medicine, 2015 - Mass Medical Soc
Many common drugs induce megaloblastic anemia by interfering with folate or vitamin B12
absorption, altering B12 metabolism, or blocking pathways in which these vitamins play a …
absorption, altering B12 metabolism, or blocking pathways in which these vitamins play a …
Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites
Human malaria parasites proliferate in different erythroid cell types during infection. Whilst
Plasmodium vivax exhibits a strong preference for immature reticulocytes, the more …
Plasmodium vivax exhibits a strong preference for immature reticulocytes, the more …
Plasmodium purine metabolism and its inhibition by nucleoside and nucleotide analogues
T Cheviet, I Lefebvre-Tournier, S Wein… - Journal of Medicinal …, 2019 - ACS Publications
Malaria still affects around 200 million people and is responsible for more than 400,000
deaths per year, mostly children in subequatorial areas. This disease is caused by parasites …
deaths per year, mostly children in subequatorial areas. This disease is caused by parasites …
Antimalarials in development in 2014
DS Barnett, RK Guy - Chemical reviews, 2014 - ACS Publications
Malaria continues to be a devastating burden on the world, causing the deaths of an
estimated 627000 people in 2012, with 482 000 of those being children under the age of 5 …
estimated 627000 people in 2012, with 482 000 of those being children under the age of 5 …
Dihydroorotate dehydrogenase: a drug target for the development of antimalarials
Malaria is a critical human disease with extensive exploration yet unestablished due to
occurrence of frequent drug resistance. This aspect of malaria pharmacology calls for the …
occurrence of frequent drug resistance. This aspect of malaria pharmacology calls for the …
Capturing in vivo RNA transcriptional dynamics from the malaria parasite Plasmodium falciparum
To capture the transcriptional dynamics within proliferating cells, methods to differentiate
nascent transcription from preexisting mRNAs are desired. One approach is to label newly …
nascent transcription from preexisting mRNAs are desired. One approach is to label newly …
Evaluation of Current and Emerging Antimalarial Medicines for Inhibition of Toxoplasma gondii Growth in Vitro
JB Radke, JN Burrows, DE Goldberg… - ACS infectious …, 2018 - ACS Publications
Toxoplasma gondii is a common zoonotic infection of humans, and estimates indicate that 1–
2 billion people are chronically infected. Although largely asymptomatic, chronic infection …
2 billion people are chronically infected. Although largely asymptomatic, chronic infection …