[HTML][HTML] Metabolic interactions between Toxoplasma gondii and its host

M Blume, F Seeber - F1000Research, 2018 - ncbi.nlm.nih.gov
Toxoplasma gondii is an obligate intracellular parasite belonging to the phylum
Apicomplexa that infects all warm-blooded animals, including humans. T. gondii can …

Utility of the biosynthetic folate pathway for targets in antimicrobial discovery

CR Bourne - Antibiotics, 2014 - mdpi.com
The need for new antimicrobials is great in face of a growing pool of resistant pathogenic
organisms. This review will address the potential for antimicrobial therapy based on …

Purine Salvage Pathways in the Intraerythrocytic Malaria Parasite Plasmodium falciparum

MJ Downie, K Kirk, CB Mamoun - Eukaryotic cell, 2008 - Am Soc Microbiol
Malaria is caused by protozoan parasites of the genus Plasmodium. Five species of
Plasmodium cause infection in humans, with the majority of lethal cases caused by …

Drug-induced megaloblastic anemia

CS Hesdorffer, DL Longo - New England Journal of Medicine, 2015 - Mass Medical Soc
Many common drugs induce megaloblastic anemia by interfering with folate or vitamin B12
absorption, altering B12 metabolism, or blocking pathways in which these vitamins play a …

Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites

A Srivastava, DJ Creek, KJ Evans, D De Souza… - PLoS …, 2015 - journals.plos.org
Human malaria parasites proliferate in different erythroid cell types during infection. Whilst
Plasmodium vivax exhibits a strong preference for immature reticulocytes, the more …

Plasmodium purine metabolism and its inhibition by nucleoside and nucleotide analogues

T Cheviet, I Lefebvre-Tournier, S Wein… - Journal of Medicinal …, 2019 - ACS Publications
Malaria still affects around 200 million people and is responsible for more than 400,000
deaths per year, mostly children in subequatorial areas. This disease is caused by parasites …

Antimalarials in development in 2014

DS Barnett, RK Guy - Chemical reviews, 2014 - ACS Publications
Malaria continues to be a devastating burden on the world, causing the deaths of an
estimated 627000 people in 2012, with 482 000 of those being children under the age of 5 …

Dihydroorotate dehydrogenase: a drug target for the development of antimalarials

A Singh, M Maqbool, M Mobashir, N Hoda - European Journal of Medicinal …, 2017 - Elsevier
Malaria is a critical human disease with extensive exploration yet unestablished due to
occurrence of frequent drug resistance. This aspect of malaria pharmacology calls for the …

Capturing in vivo RNA transcriptional dynamics from the malaria parasite Plasmodium falciparum

HJ Painter, M Carrasquilla, M Llinás - Genome research, 2017 - genome.cshlp.org
To capture the transcriptional dynamics within proliferating cells, methods to differentiate
nascent transcription from preexisting mRNAs are desired. One approach is to label newly …

Evaluation of Current and Emerging Antimalarial Medicines for Inhibition of Toxoplasma gondii Growth in Vitro

JB Radke, JN Burrows, DE Goldberg… - ACS infectious …, 2018 - ACS Publications
Toxoplasma gondii is a common zoonotic infection of humans, and estimates indicate that 1–
2 billion people are chronically infected. Although largely asymptomatic, chronic infection …