Malaria is a tropical disease that kills about half a million people around the world annually.
Enzymatic reactions within pyrimidine biosynthesis have been proven to be essential for …

The present work investigates the potential for enhancing the NMR signals of DNA
nucleobases by parahydrogen-based hyperpolarization. Signal amplification by reversible …

Toxoplasma gondii (T. gondii) is a cosmopolitan protozoan parasite in humans and animals.
It infects about 30% of the human population worldwide and causes potentially fatal …

Background Malaria infection can result in distinct clinical outcomes from asymptomatic to
severe. The association between patho-physiological changes and molecular changes in …

Plasmodium falciparum and vivax are responsible for the majority of malaria infections
worldwide, resulting in over a million deaths annually. Malaria parasites now show …

Hypoxanthine, a nucleobase, serves as the major source of the essential purine group for
the intraerythrocytic malaria parasite. In this study we have measured the uptake of …

Uracil phosphoribosyltransferase (UPRT) is a pyrimidine salvage pathway enzyme that
catalyzes the conversion of uracil to uridine monophosphate (UMP). The enzyme is highly …

Coenzyme A (CoA) is an essential cofactor for numerous cellular reactions in all living
organisms. In the protozoan parasite Entamoeba histolytica, CoA is synthesized in a …

Cytidine triphosphate synthase catalyzes the synthesis of cytidine 5′-triphosphate (CTP)
from uridine 5′-triphosphate (UTP), the final step in the production of cytidine nucleotides …

Publisher Summary This chapter reviews the syntheses and reactions of 6-membered
heterocyclic ring systems, such as diazines and benzo derivatives. The diazines pyridazine …