Impact of alternative splicing variants on liver cancer biology

JJG Marin, M Reviejo, M Soto, E Lozano, M Asensio… - Cancers, 2021 - mdpi.com
Simple Summary Among the top ten deadly solid tumors are the two most frequent liver
cancers, hepatocellular carcinoma, and intrahepatic cholangiocarcinoma, whose …

[HTML][HTML] Alternative splicing and liver disease

M Baralle, FE Baralle - Annals of hepatology, 2021 - Elsevier
Alternative splicing produces complex and dynamic changes in the protein isoforms that are
necessary for the proper biological functioning of the metabolic pathways involved in liver …

Dysregulation of RNA splicing in early non-alcoholic fatty liver disease through hepatocellular carcinoma

NJG Webster, D Kumar, P Wu - Scientific Reports, 2024 - nature.com
While changes in RNA splicing have been extensively studied in hepatocellular carcinoma
(HCC), no studies have systematically investigated changes in RNA splicing during earlier …

Hepatocyte deletion of IGF2 prevents DNA damage and tumor formation in hepatocellular carcinoma

D Kumar, M Das, A Oberg, D Sahoo, P Wu… - Advanced …, 2022 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Serine‐
arginine rich splicing factor 3 (SRSF3) plays a critical role in hepatocyte function and its loss …

Immunological significance of prognostic alternative splicing signature in hepatocellular carcinoma

Q Xu, H Xu, R Deng, N Li, R Mu, Z Qi, Y Shen… - Cancer cell …, 2021 - Springer
Background Hepatocellular carcinoma (HCC) ranks the sixth prevalent tumors with high
mortality globally. Alternative splicing (AS) drives protein diversity, the imbalance of which …

Identification of drug targets and prognosis projection for uterine carcinosarcoma based on alternative splicing events

X Zhang, X Yin, L Zhang, Z Ye, G Liang - Computers in Biology and …, 2023 - Elsevier
Background Uterine carcinosarcoma (UCS) is an invasive variant of endometrial cancer.
The complicated heterogeneity and low frequency of UCS suggest the relevant research is …

Decoding the role of aberrant RNA alternative splicing in hepatocellular carcinoma: a comprehensive review

M Sheng, Y Zhang, Y Wang, W Liu, X Wang… - Journal of Cancer …, 2023 - Springer
During eukaryotic gene expression, alternative splicing of messenger RNA precursors is
critical in increasing protein diversity and regulatory complexity. Multiple transcript isoforms …

A systems biology‐based approach to screen key splicing factors in hepatocellular carcinoma

R Zhu, X Wang, Q Yu, W Guo… - Molecular Carcinogenesis, 2023 - Wiley Online Library
A splicing factor is as an important upstream regulator of the alternative splicing process.
Hence, it is considered to be a therapeutic target for hepatocellular carcinoma (HCC) …

[HTML][HTML] Identification of prognostic alternative splicing signatures in hepatitis B or/and C viruses related hepatocellular carcinoma

Y Cai, J Xia, N Wang, H Zhou - Genomics, 2020 - Elsevier
Background Alternative splicing (AS) takes a crucial part in tumor process. We aim to
analyze AS in Hepatitis B virus (HBV) or/and hepatitis C virus (HCV) related hepatocellular …

Aberrant RNA splicing events driven by mutations of RNA-binding proteins as indicators for skin cutaneous melanoma prognosis

C Mei, PY Song, W Zhang, HH Zhou, X Li… - Frontiers in …, 2020 - frontiersin.org
The worldwide incidence of skin cutaneous melanoma (SKCM) is increasing at a more rapid
rate than other tumors. Aberrant alternative splicing (AS) is found to be common in cancer; …