[HTML][HTML] Potential role of ginger (Zingiber officinale Roscoe) in the prevention of neurodegenerative diseases

R Arcusa, D Villaño, J Marhuenda, M Cano… - Frontiers in …, 2022 - frontiersin.org
Ginger is composed of multiple bioactive compounds, including 6-gingerol, 6-shogaol, 10-
gingerol, gingerdiones, gingerdiols, paradols, 6-dehydrogingerols, 5-acetoxy-6-gingerol, 3 …

The role of uptake and efflux transporters in the disposition of glucuronide and sulfate conjugates

E Järvinen, F Deng, W Kiander, A Sinokki… - Frontiers in …, 2022 - frontiersin.org
Glucuronidation and sulfation are the most typical phase II metabolic reactions of drugs. The
resulting glucuronide and sulfate conjugates are generally considered inactive and safe …

Regulation of drug transport proteins—From mechanisms to clinical impact: A white paper on behalf of the international transporter consortium

KLR Brouwer, R Evers, E Hayden, S Hu… - Clinical …, 2022 - Wiley Online Library
Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or
toxicity of many drugs. Numerous mechanisms (eg, nuclear receptors, epigenetic gene …

The use of antibiotics and antimicrobial resistance in veterinary medicine, a complex phenomenon: a narrative review

A Caneschi, A Bardhi, A Barbarossa, A Zaghini - Antibiotics, 2023 - mdpi.com
As warned by Sir Alexander Fleming in his Nobel Prize address:“the use of antimicrobials
can, and will, lead to resistance”. Antimicrobial resistance (AMR) has recently increased due …

Update on drug-drug interaction at organic cation transporters: mechanisms, clinical impact, and proposal for advanced in vitro testing

H Koepsell - Expert Opinion on Drug Metabolism & Toxicology, 2021 - Taylor & Francis
Introduction: Organic cation transporters collectively called OCTs belong to three gene
families (SLC22A1 OCT1, SLC22A2 OCT2, SLC22A3 OCT3, SLC22A4 OCTN1, SLC22A5 …

Toxicity induced by ciprofloxacin and enrofloxacin: oxidative stress and metabolism

S Badawy, YQ Yang, Y Liu, MA Marawan… - Critical Reviews in …, 2021 - Taylor & Francis
Abstract Ciprofloxacin (CIP)(human use) and enrofloxacin (ENR)(veterinary use) are
synthetic anti-infectious medications that belong to the second generation of …

Drug-drug interactions between psychotropic medications and oral contraceptives

G Schoretsanitis, KM Deligiannidis… - Expert opinion on …, 2022 - Taylor & Francis
Introduction This is a comprehensive overview of pharmacokinetic drug-drug interactions
(DDIs) involving oral contraceptives (OCs) and psychotropic medications. Areas covered …

Hepatic solute carrier transporters and drug therapy: Regulation of expression and impact of genetic variation

AT Nies, E Schaeffeler, M Schwab - Pharmacology & Therapeutics, 2022 - Elsevier
Organic cation transporters (OCT), organic anion transporting polypeptides (OATP) and
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …

Identification of glycochenodeoxycholate 3‐O‐glucuronide and glycodeoxycholate 3‐O‐glucuronide as highly sensitive and specific OATP1B1 biomarkers

M Neuvonen, P Hirvensalo, A Tornio… - Clinical …, 2021 - Wiley Online Library
The aim of this study was to investigate the sensitivity and specificity of endogenous
glycochenodeoxycholate and glycodeoxycholate 3‐O‐glucuronides (GCDCA‐3G and …

Reimagining the framework supporting the static analysis of transporter drug interaction risk; integrated use of biomarkers to generate pan‐transporter inhibition …

AD Rodrigues - Clinical Pharmacology & Therapeutics, 2023 - Wiley Online Library
Solute carrier (SLC) transporters present as the loci of important drug–drug interactions
(DDIs). Therefore, sponsors generate in vitro half‐maximal inhibitory concentration (IC50) …