Raman spectroscopy for chemical biology research

K Dodo, K Fujita, M Sodeoka - Journal of the American Chemical …, 2022 - ACS Publications
In chemical biology research, various fluorescent probes have been developed and used to
visualize target proteins or molecules in living cells and tissues, yet there are limitations to …

The emerging role of Raman spectroscopy as an omics approach for metabolic profiling and biomarker detection toward precision medicine

G Cutshaw, S Uthaman, N Hassan… - Chemical …, 2023 - ACS Publications
Omics technologies have rapidly evolved with the unprecedented potential to shape
precision medicine. Novel omics approaches are imperative toallow rapid and accurate data …

Biological imaging of chemical bonds by stimulated Raman scattering microscopy

F Hu, L Shi, W Min - Nature methods, 2019 - nature.com
All molecules consist of chemical bonds, and much can be learned from mapping the
spatiotemporal dynamics of these bonds. Since its invention a decade ago, stimulated …

Instant diagnosis of gastroscopic biopsy via deep-learned single-shot femtosecond stimulated Raman histology

Z Liu, W Su, J Ao, M Wang, Q Jiang, J He, H Gao… - Nature …, 2022 - nature.com
Gastroscopic biopsy provides the only effective method for gastric cancer diagnosis, but the
gold standard histopathology is time-consuming and incompatible with gastroscopy …

Recent insights into the function of autophagy in cancer

R Amaravadi, AC Kimmelman, E White - Genes & development, 2016 - genesdev.cshlp.org
Macroautophagy (referred to here as autophagy) is induced by starvation to capture and
degrade intracellular proteins and organelles in lysosomes, which recycles intracellular …

Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine

JX Cheng, XS Xie - Science, 2015 - science.org
BACKGROUND Biomolecules can serve as natural labels for microscopy by measuring their
molecular vibration spectra in living cells and tissues. However, the transition from …

Targeting autophagy in cancer: update on clinical trials and novel inhibitors

CI Chude, RK Amaravadi - International journal of molecular sciences, 2017 - mdpi.com
Eukaryotes use autophagy as a mechanism for maintaining cellular homeostasis by
degrading and recycling organelles and proteins. This process assists in the proliferation …

Raman spectroscopy: techniques and applications in the life sciences

DW Shipp, F Sinjab, I Notingher - Advances in Optics and Photonics, 2017 - opg.optica.org
Raman spectroscopy is an increasingly popular technique in many areas, including biology
and medicine. It is based on Raman scattering, a phenomenon in which incident photons …

New modalities for challenging targets in drug discovery

E Valeur, SM Guéret, H Adihou… - Angewandte Chemie …, 2017 - Wiley Online Library
Our ever‐increasing understanding of biological systems is providing a range of exciting
novel biological targets, whose modulation may enable novel therapeutic options for many …

Determination of the subcellular localization and mechanism of action of ferrostatins in suppressing ferroptosis

MM Gaschler, F Hu, H Feng, A Linkermann… - ACS Chemical …, 2018 - ACS Publications
Ferroptosis is a form of nonapoptotic cell death characterized by the unchecked
accumulation of lipid peroxides. Ferrostatin-1 and its analogs (ferrostatins) specifically …