The human genetic basis of tuberculosis (TB) has long remained elusive. We recently
reported a high level of enrichment in homozygosity for the common TYK2 P1104A variant in …

Tyrosine kinase 2 (TYK2) is a member of the JAK kinase family that regulates signal
transduction downstream of receptors for the IL-23/IL-12 pathways and type I interferon …

Type I interferons (IFNs), mostly IFNα and IFNβ, and the type I IFN Signature are important in
the pathogenesis of Systemic Lupus Erythematosus (SLE), an autoimmune chronic …

A search for structurally diversified Tyk2 JH2 ligands from 6 (BMS-986165), a pyridazine
carboxamide-derived Tyk2 JH2 ligand as a clinical Tyk2 inhibitor currently in late …

JAKs are intracellular protein tyrosine kinases that, through activation of STATs, are
responsible for signal transduction pathways that regulate cellular responses to numerous …

Abstract The Janus kinases or JAKs are a family of intracellular tyrosine kinases that play an
essential role in the signaling of numerous cytokines that have been implicated in the …

Recent advances in immunology enabled the characterization of several signal transmitting
pathways responsible for proper cytokine and chemokine signaling. Among them, Janus …

Bullous pemphigoid (BP) and psoriasis are both immune-related skin diseases. Still, the
comorbidities between the two are rare, and there is no consensus on the optimal treatment …

Janus kinases (JAKs) are central components in cytokine signaling pathways. A number of
small molecule JAK inhibitors have been approved to treat a wide range of inflammatory and …

In this review we concentrate on the recent findings describing the oncogenic potential of the
protein tyrosine kinase 2 (TYK2). The overview on the current understanding of TYK2 …