Inflammation and psychological stress are risk factors for major depression and suicide.
Both increase central glutamate levels and activate the hypothalamic-pituitary-adrenal axis …

TYK2, a member of the JAK family of proximal membrane-bound tyrosine kinases, has
emerged as an attractive target for the treatment of autoimmune diseases. Herein, we report …

Psoriasis is a long-lasting skin condition characterized by redness and thick silver scales on
the skin's surface. It involves various skin cells, including keratinocytes, dendritic cells, T …

Tyrosine kinase 2 (TYK2) mediates the interleukin-23 (IL-23), IL-12, and type I interferon
(IFN)-driven signal responses that are critical in autoimmune diseases. Here, a series of …

TYK2 is a member of the JAK family of kinases and a key mediator of IL-12, IL-23, and type I
interferon signaling. These cytokines have been implicated in the pathogenesis of multiple …

Background As a member of the Janus kinase (JAK) family, which includes JAK1, JAK2 and
JAK3, tyrosine kinase 2 (TYK2) plays an important role in signal transduction and immune …

We review the history of the tyrosine kinase 2 (TYK2) as the founding member of the Janus
kinase (JAK) family and outline its structure-function relation. Gene-targeted mice and …

Introduction Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory skin
disorder characterized by painful nodules, abscesses, fistulae, and scarring with a …

TYK2 is an emerging drug target for various human autoimmune diseases. However,
discovery of selective TYK2 inhibitor over other JAK family members (ie, JAK1, 2, 3) by …

Abstract Tyrosine kinase 2 (TYK2) is a member of the Janus kinase (JAK) family, which can
regulate the signaling of multiple pro-inflammatory cytokines, including IL12, IL23 and type I …