Translation of modulation of drug target activity to therapeutic effect is a critical aspect for all
drug discovery programs. In this work we describe the profiling of a non-receptor tyrosine …

Introduction: Rheumatoid arthritis (RA) is a chronic, refractory disorder caused by
autoimmunity in the synovial joints. Disease-modifying anti-rheumatic drugs (DMARDs) and …

Introduction: Rare genetic functional variants can contribute to 30-40% of functional
variability in genes relevant to drug action. Therefore, we investigated the role of rare …

Background Janus kinase (JAK)/tyrosine kinase 2 (TYK2) inhibitors are novel treatments for
moderate-to-severe plaque psoriasis. Objective To perform a network meta-analysis to …

Janus kinase (JAK) is a family of intracellular non-receptor tyrosine kinases with four
members (JAK1, JAK2, JAK3, and Tyk2). The JAK-STAT (signal transducer and activator of …

Abstract Tyrosine kinase 2 (TYK2) is a member of the Janus kinase (JAK) family, which plays
an important part in signal transduction and regulation of the immune system. To minimize …

A Sc (OTf) 3 catalyzed [3+ 2]-annulation reaction between donor–acceptor aziridines and
several exo-glycals has been developed. Using this method, some exo-glycals derived from …

Due to the complexity of the pathogenesis of systemic lupus erythematosus (SLE), the
research and development of drugs targeting different pathogenesis or targets of SLE and …

Psoriasis is a hyperproliferative skin disorder which is associated with dysregulation of the
immune system. In this genetically transmitted disease, the immune system is activated by …

Изучены спектральные характеристики дитиомалондианилида (N, N′-
дифенилдитиомалондиамида), методом потенциометрического титрования …