The aims of the current study were to develop and evaluate clindamycin palmitate
hydrochloride (CPH) 3D-printed tablets (printlets) manufactured by selective laser sintering …

A drug is a chemical substance which possesses medicinal properties and exerts
pharmacological action upon administration into the body. When a drug gets metabolized …

Objective: The review covers basic principles of the prodrug strategy applied to antiviral
nucleoside drugs or drug candidates. Specific role of amino acids as promoieties is …

For the first time, isoniazid (INH) bitterness value, threshold, and sensitivity (low, moderate,
high, and extremely high) was determined in six human volunteers. INH demonstrated a …

Abstract N-lauroyl-L-tryptophan (LT), which has the strongest potential flavor-presenting
activity, was skillfully screened from numerous N-Lau-AAs docked to different taste receptors …

Enzymes are highly specific biological catalysts that accelerate the rate of chemical
reactions within the cell. Our knowledge of how enzymes work remains incomplete …

Amino acids derived prodrugs emerged as an attractive approach to improve oral delivery of
drugs with low solubility and permeability. Conjugation of amino acids with parent drug …

A respected number of drugs suffer from bitter taste which results in patient incompliance.
With the aim of solving the bitterness of guaifenesin, dimethyl maleate, maleate, glutarate …

As the role of taste receptors in food-intake regulation is being unraveled, agonists and
antagonists of bitter taste receptors will have additional important roles in modulating food …

The prodrug concept is a very useful approach for the optimization of ADMET (absorption,
distribution, metabolism, excretion, and toxicity) properties of pharmacologically active …