Objective: Antipsychotic drug efficacy may have decreased over recent decades. The
authors present a meta-analysis of all placebo-controlled trials in patients with acute …

Objective To study serious harms associated with selective serotonin and serotonin-
norepinephrine reuptake inhibitors. Design Systematic review and meta-analysis. Main …

The long‐term benefit‐to‐risk ratio of sustained antipsychotic treatment for schizophrenia
has recently been questioned. In this paper, we critically examine the literature on the long …

An important goal of biomedical research is to translate basic research findings into useful
medical advances. In the field of neuropharmacology this requires understanding disease …

How do the good become great? Practice! From musicians and executives to physicians and
drivers, aspiring professionals rely on deliberate practice to attain expertise. Recently …

Concerns have been raised that treatment with antipsychotic medication might adversely
affect long-term outcomes for people with schizophrenia. The evidence cited for these …

Recent evidence suggests that psychotherapists may not increase in effectiveness over
accrued experience in naturalistic settings, even settings that provide access to patients' …

Abstract Background: Antidepressants (ADs) are commonly prescribed medications, but
their long-term health effects are debated. ADs disrupt multiple adaptive processes …

Lithium (Li+) is a first option treatment for adult acute episodes of Bipolar Disorder (BD) and
for the prophylaxis of new depressed or manic episodes. It is also the preferred choice as …

As there is currently no comprehensive evaluation about the efficacy and safety of
interventions in elderly patients with major depressive disorder, we did a systematic review …