The central nervous system (CNS) is an immunologically privileged site to which access of
circulating immune cells is tightly controlled by the endothelial blood–brain barrier (BBB; see …

Studies of the choroid plexus lag behind those of the more widely known blood-brain barrier,
despite a much longer history. This review has two overall aims. The first is to outline long …

Amyotrophic lateral sclerosis (ALS) is a heterogenous neurodegenerative disorder that
affects motor neurons and voluntary muscle control. ALS heterogeneity includes the age of …

To perform their distinct effector functions, pathogen‐specific T cells have to migrate to target
tissue where they recognize antigens and produce cytokines that elicit appropriate types of …

Background: Dimethyl fumarate (DMF) alters the phenotype of circulating immune cells and
causes lymphopenia in a subpopulation of treated multiple sclerosis (MS) patients …

Background Dimethyl fumarate (DMF), a disease-modifying therapy for multiple sclerosis
(MS), causes lymphopenia in a fraction of patients. The clinical significance of this is …

Single-cell technologies allow precise identification of tumor composition at the single-cell
level, providing high-resolution insights into the intratumoral heterogeneity and …

Accumulating evidence shows that T cells penetrate the central nervous system (CNS)
parenchyma in several autoimmune, infectious, and degenerative neurological diseases …

Norovirus (NV) gastroenteritis is a major contributor to global morbidity and mortality, yet
little is known about immune mechanisms leading to NV control. Previous studies using the …

The use of antiretroviral therapy (ART) for Human Immunodeficiency Virus (HIV) treatment
has been highly successful in controlling plasma viremia to undetectable levels. However, a …