Combination strategies with PD-1/PD-L1 blockade: current advances and future directions
M Yi, X Zheng, M Niu, S Zhu, H Ge, K Wu - Molecular cancer, 2022 - Springer
Antibodies targeting programmed cell death protein-1 (PD-1) or its ligand PD-L1 rescue T
cells from exhausted status and revive immune response against cancer cells. Based on the …
cells from exhausted status and revive immune response against cancer cells. Based on the …
Translational applications of hydrogels
Advances in hydrogel technology have unlocked unique and valuable capabilities that are
being applied to a diverse set of translational applications. Hydrogels perform functions …
being applied to a diverse set of translational applications. Hydrogels perform functions …
Bioengineered nanogels for cancer immunotherapy
Recent years have witnessed increasingly rapid advances in nanocarrier-based
biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as …
biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as …
Calcium carbonate: controlled synthesis, surface functionalization, and nanostructured materials
YQ Niu, JH Liu, C Aymonier, S Fermani… - Chemical Society …, 2022 - pubs.rsc.org
Calcium carbonate (CaCO3) is an important inorganic mineral in biological and geological
systems. Traditionally, it is widely used in plastics, papermaking, ink, building materials …
systems. Traditionally, it is widely used in plastics, papermaking, ink, building materials …
[HTML][HTML] An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing
Prolonged, intense inflammation and excessive oxidative stress hinder diabetic wounds
from healing normally, leading to disorders downstream including the postponement of re …
from healing normally, leading to disorders downstream including the postponement of re …
Curvature-sensing peptide inhibits tumour-derived exosomes for enhanced cancer immunotherapy
Tumour-derived exosomes (T-EXOs) impede immune checkpoint blockade therapies,
motivating pharmacological efforts to inhibit them. Inspired by how antiviral curvature …
motivating pharmacological efforts to inhibit them. Inspired by how antiviral curvature …
Boosting checkpoint immunotherapy with biomaterials
The immune checkpoint blockade (ICB) therapy has revolutionized the field of cancer
treatment, while low response rates and systemic toxicity limit its clinical outcomes. With the …
treatment, while low response rates and systemic toxicity limit its clinical outcomes. With the …
An injectable hydrogel using an immunomodulating gelator for amplified tumor immunotherapy by blocking the arginase pathway
X Ren, N Wang, Y Zhou, A Song, G Jin, Z Li, Y Luan - Acta biomaterialia, 2021 - Elsevier
Abstract Arginase 1 (ARG1) inactivates T cells by degrading L-arginine, severely reducing
the immunotherapeutic efficacy. Effectively blocking the ARG1 pathway remains a …
the immunotherapeutic efficacy. Effectively blocking the ARG1 pathway remains a …
Nanoparticle–hydrogel superstructures for biomedical applications
The incorporation of nanoparticles into hydrogels yields novel superstructures that have
become increasingly popular in biomedical research. Each component of these nanoparticle …
become increasingly popular in biomedical research. Each component of these nanoparticle …
Efficient immunotherapy of drug-free layered double hydroxide nanoparticles via neutralizing excess acid and blocking tumor cell autophagy
Cancer immunotherapy efficacy is largely limited by the suppressive tumor immune
microenvironment (TIME) where antitumor immune cells are inhibited and tumor antigens …
microenvironment (TIME) where antitumor immune cells are inhibited and tumor antigens …