[HTML][HTML] Identification and characterization of post-translational modifications: Clinical implications
J Hermann, L Schurgers, V Jankowski - Molecular aspects of medicine, 2022 - Elsevier
Post-translational modifications (PTMs) generate marginally modified isoforms of native
peptides, proteins and lipoproteins thereby regulating protein functions, molecular …
peptides, proteins and lipoproteins thereby regulating protein functions, molecular …
A global view of the human post-translational modification landscape
N Kitamura, JJ Galligan - Biochemical Journal, 2023 - portlandpress.com
Post-translational modifications (PTMs) provide a rapid response to stimuli, finely tuning
metabolism and gene expression and maintain homeostasis. Advances in mass …
metabolism and gene expression and maintain homeostasis. Advances in mass …
[HTML][HTML] The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function
M Wenes, A Jaccard, T Wyss, N Maldonado-Pérez… - Cell Metabolism, 2022 - cell.com
Glycolysis, including both lactate fermentation and pyruvate oxidation, orchestrates CD8+ T
cell differentiation. However, how mitochondrial pyruvate metabolism and uptake controlled …
cell differentiation. However, how mitochondrial pyruvate metabolism and uptake controlled …
Single substitution in H3. 3G34 alters DNMT3A recruitment to cause progressive neurodegeneration
Germline histone H3. 3 amino acid substitutions, including H3. 3G34R/V, cause severe
neurodevelopmental syndromes. To understand how these mutations impact brain …
neurodevelopmental syndromes. To understand how these mutations impact brain …
Current methods of post-translational modification analysis and their applications in blood cancers
Simple Summary This review discusses current techniques used to study post-translational
protein modifications (PTMs) and their contribution to blood cancer research. Blood cancer …
protein modifications (PTMs) and their contribution to blood cancer research. Blood cancer …
Histone butyrylation in the mouse intestine is mediated by the microbiota and associated with regulation of gene expression
Post-translational modifications (PTMs) on histones are a key source of regulation on
chromatin through impacting cellular processes, including gene expression. These PTMs …
chromatin through impacting cellular processes, including gene expression. These PTMs …
Stable isotope tracing in vivo reveals a metabolic bridge linking the microbiota to host histone acetylation
PJ Lund, LA Gates, M Leboeuf, SA Smith, L Chau… - Cell reports, 2022 - cell.com
The gut microbiota influences acetylation on host histones by fermenting dietary fiber into
butyrate. Although butyrate could promote histone acetylation by inhibiting histone …
butyrate. Although butyrate could promote histone acetylation by inhibiting histone …
Stable isotopes for tracing cardiac metabolism in diseases
A Karlstaedt - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
Although metabolic remodeling during cardiovascular diseases has been well-recognized
for decades, the recent development of analytical platforms and mathematical tools has …
for decades, the recent development of analytical platforms and mathematical tools has …
Hepatic X‐Box Binding Protein 1 and Unfolded Protein Response Is Impaired in Weanling Mice With Resultant Hepatic Injury
A Kriegermeier, A Hyon, M Sommars, S Hubchak… - …, 2021 - Wiley Online Library
Background and Aims The unfolded protein response (UPR) is a coordinated cellular
response to endoplasmic reticulum (ER) stress that functions to maintain cellular …
response to endoplasmic reticulum (ER) stress that functions to maintain cellular …
Global microbiota‐dependent histone acetylation patterns are irreversible and independent of short chain fatty acids
Y Saiman, TCD Shen, PJ Lund, VM Gershuni… - …, 2021 - Wiley Online Library
Background and Aims Although germ‐free mice are an indispensable tool in studying the
gut microbiome and its effects on host physiology, they are phenotypically different than their …
gut microbiome and its effects on host physiology, they are phenotypically different than their …