Transforming growth factor-β signaling: from tissue fibrosis to therapeutic opportunities
LL Ren, XJ Li, TT Duan, ZH Li, JZ Yang… - Chemico-biological …, 2023 - Elsevier
Fibrosis refers to the excessive deposition of extracellular matrix components in the
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in …
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in …
[HTML][HTML] Membranous nephropathy: systems biology-based novel mechanism and traditional Chinese medicine therapy
H Miao, Y Zhang, X Yu, L Zou, Y Zhao - Frontiers in pharmacology, 2022 - frontiersin.org
Membranous nephropathy (MN) is a renal-limited non-inflammatory autoimmune disease in
the glomerulus, which is the second or third main cause of end-stage kidney diseases in …
the glomerulus, which is the second or third main cause of end-stage kidney diseases in …
Lactobacillus species ameliorate membranous nephropathy through inhibiting the aryl hydrocarbon receptor pathway via tryptophan‐produced indole metabolites
H Miao, YN Wang, XY Yu, L Zou, Y Guo… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Membranous nephropathy (MN) is an immune‐mediated
glomerular disease in adults. Antibody‐and antigen‐bonding mechanisms have been …
glomerular disease in adults. Antibody‐and antigen‐bonding mechanisms have been …
Integrative phosphatidylcholine metabolism through phospholipase A2 in rats with chronic kidney disease
Y Wang, Z Zhang, H Liu, Z Guo, L Zou… - Acta Pharmacologica …, 2023 - nature.com
Dysregulation in lipid metabolism is the leading cause of chronic kidney disease (CKD) and
also the important risk factors for high morbidity and mortality. Although lipid abnormalities …
also the important risk factors for high morbidity and mortality. Although lipid abnormalities …
Moshen granule ameliorates membranous nephropathy by blocking intrarenal renin-angiotensin system signalling via the Wnt1/β-catenin pathway
YN Wang, H Miao, MR Hua, JZ Yang, M Pei, HX Yu… - Phytomedicine, 2023 - Elsevier
Background Membranous nephropathy (MN) is one of the cardinal causes of nephrotic
syndrome in adults, but an adequate treatment regimen is lacking. Purpose We assessed …
syndrome in adults, but an adequate treatment regimen is lacking. Purpose We assessed …
[HTML][HTML] Shenkang injection improves chronic kidney disease by inhibiting multiple renin-angiotensin system genes by blocking the Wnt/β-catenin signalling pathway
YN Wang, HJ Liu, LL Ren, P Suo, L Zou… - Frontiers in …, 2022 - frontiersin.org
Chronic kidney disease (CKD) is a major worldwide public health problem. The increase in
the number of patients with CKD and end-stage kidney disease requesting renal dialysis or …
the number of patients with CKD and end-stage kidney disease requesting renal dialysis or …
Membranous nephropathy: mechanistic insights and therapeutic perspectives
MR Hua, YL Zhao, JZ Yang, L Zou, YY Zhao… - International …, 2023 - Elsevier
Membranous nephropathy (MN) is one of the most common causes of non-diabetic
nephrotic syndrome in adults. About 80% of cases are renal limited (primary MN) and 20 …
nephrotic syndrome in adults. About 80% of cases are renal limited (primary MN) and 20 …
Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin pathway
H Miao, Y Wang, W Su, L Zou, S Zhuang, X Yu… - Acta Pharmacologica …, 2024 - nature.com
Sirtuins (Sirts) are a family of nicotinamide adenine dinucleotide-dependent protein
deacetylases that share diverse cellular functions. Increasing evidence shows that Sirts play …
deacetylases that share diverse cellular functions. Increasing evidence shows that Sirts play …
Oxidative stress and inflammation are mediated via aryl hydrocarbon receptor signalling in idiopathic membranous nephropathy
YN Wang, H Miao, XY Yu, Y Guo, W Su, F Liu… - Free Radical Biology …, 2023 - Elsevier
Membranous nephropathy (MN) patients are diagnosed by the presence of phospholipase A
2 receptor (PLA2R) before they progress to renal failure. However, the subepithelium-like …
2 receptor (PLA2R) before they progress to renal failure. However, the subepithelium-like …
[HTML][HTML] The nuclear factor kappa B signaling pathway is a master regulator of renal fibrosis
N Ren, WF Wang, L Zou, YL Zhao, H Miao… - Frontiers in …, 2024 - frontiersin.org
Renal fibrosis is increasingly recognized as a global public health problem. Acute kidney
injury (AKI) and chronic kidney disease (CKD) both result in renal fibrosis. Oxidative stress …
injury (AKI) and chronic kidney disease (CKD) both result in renal fibrosis. Oxidative stress …