Monoclonal antibody (mAb) therapy was first established upon the approval of a mouse
antibody for treatment of human acute organ rejection. However, the high incidence of …

Background We analysed incidence, predictors, histological features and specific treatment
options of anti-tumour necrosis factor α (TNF-α) antibody-induced psoriasiform skin lesions …

The skin provides the first line defense of the human body against injury and infection. By
integrating recent findings in cutaneous immunology with fundamental concepts of skin …

Recent advances in genome-wide association studies (GWAS) across autoimmune and
immune-mediated diseases have augmented our understanding of pathogenic mechanisms …

Spondyloarthritis (SpA) represents a group of immune-mediated inflammatory diseases that
exhibit overlapping clinical features, genetic predisposition, and pathogenic mechanisms (1) …

Psoriasis is a chronic skin inflammatory disorder, the immune mechanism of which has been
profoundly elucidated in the past few years. The dominance of the interleukin (IL)‐23/IL‐17 …

Biologic therapies that target pathogenic cytokines such as TNF, IL-1β or IL-6 have greatly
improved the treatment of RA. Unfortunately, not all RA patients respond to current biologic …

Objective Ankylosing spondylitis (AS) is a common inflammatory arthritis affecting primarily
the axial skeleton. IL23R is genetically associated with AS. This study was undertaken to …

Abstract Objective The spondylarthritides (SpA), including ankylosing spondylitis (AS),
psoriatic arthritis (PsA), reactive arthritis, and arthritis associated with inflammatory bowel …

Recent studies have greatly improved our insight into the genetic background of
inflammatory bowel disease (IBD). New high‐throughput technologies and large‐scale …