Antibiotic perturbations to the gut microbiome

SRS Fishbein, B Mahmud, G Dantas - Nature Reviews Microbiology, 2023 - nature.com
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …

Examining horizontal gene transfer in microbial communities

IL Brito - Nature Reviews Microbiology, 2021 - nature.com
Bacteria acquire novel DNA through horizontal gene transfer (HGT), a process that enables
an organism to rapidly adapt to changing environmental conditions, provides a competitive …

Understanding the impact of antibiotic perturbation on the human microbiome

DJ Schwartz, AE Langdon, G Dantas - Genome medicine, 2020 - Springer
The human gut microbiome is a dynamic collection of bacteria, archaea, fungi, and viruses
that performs essential functions for immune development, pathogen colonization …

Gut microbiome dysbiosis is associated with increased mortality after solid organ transplantation

JC Swarte, Y Li, S Hu, JR Björk, R Gacesa… - Science Translational …, 2022 - science.org
Organ transplantation is a life-saving treatment for patients with end-stage disease, but
survival rates after transplantation vary considerably. There is now increasing evidence that …

[HTML][HTML] Antibiotic resistance in the commensal human gut microbiota

LE Lamberte, W van Schaik - Current Opinion in Microbiology, 2022 - Elsevier
Highlights•The human gut microbiota serves as a reservoir of antibiotic resistance
genes.•DNA sequencing and culture techniques are used to characterise the gut …

Widespread transfer of mobile antibiotic resistance genes within individual gut microbiomes revealed through bacterial Hi-C

AG Kent, AC Vill, Q Shi, MJ Satlin, IL Brito - Nature Communications, 2020 - nature.com
The gut microbiome harbors a 'silent reservoir'of antibiotic resistance (AR) genes that is
thought to contribute to the emergence of multidrug-resistant pathogens through horizontal …

Effects of antibiotic treatment on gut microbiota and how to overcome its negative impacts on human health

CFA Ribeiro, GGOS Silveira, ES Candido… - ACS Infectious …, 2020 - ACS Publications
The need for new antimicrobial therapies is evident, especially to reduce antimicrobial
resistance and minimize deleterious effects on gut microbiota. However, although diverse …

Predictable modulation of cancer treatment outcomes by the gut microbiota

Y Heshiki, R Vazquez-Uribe, J Li, Y Ni, S Quainoo… - Microbiome, 2020 - Springer
The gut microbiota has the potential to influence the efficacy of cancer therapy. Here, we
investigated the contribution of the intestinal microbiome on treatment outcomes in a …

Probiotics Bifidobacterium lactis M8 and Lactobacillus rhamnosus M9 prevent high blood pressure via modulating the gut microbiota composition and host metabolic …

Y Zhang, T Zheng, D Ma, P Shi, H Zhang, J Li, Z Sun - Msystems, 2023 - Am Soc Microbiol
High-fructose intake is one of the high-risk factors for hypertension. Several probiotics have
been reported to reduce high blood pressure (BP) via modulating gut microbiota, but the …

[HTML][HTML] Emerging frontiers of antibiotics use and their impacts on the human gut microbiome

R Kumari, Y Yadav, R Misra, U Das, UD Adhikari… - Microbiological …, 2022 - Elsevier
Antibiotics, the primary drugs used to cure bacterial diseases, are increasingly becoming
ineffective due to the emergence of multiple drug resistance (MDR) leading to recurrence of …