Aspergillus fumigatus and Aspergillosis in 2019

JP Latgé, G Chamilos - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

[HTML][HTML] Fungal iron homeostasis with a focus on Aspergillus fumigatus

M Misslinger, P Hortschansky, AA Brakhage… - Biochimica et Biophysica …, 2021 - Elsevier
To maintain iron homeostasis, fungi have to balance iron acquisition, storage, and utilization
to ensure sufficient supply and to avoid toxic excess of this essential trace element. As …

[HTML][HTML] Secretion of the siderophore rhizoferrin is regulated by the cAMP-PKA pathway and is involved in the virulence of Mucor lusitanicus

V Alejandre-Castañeda, JA Patiño-Medina… - Scientific Reports, 2022 - nature.com
Mucormycosis is a fungal infection caused by Mucorales, with a high mortality rate.
However, only a few virulence factors have been described in these organisms. This study …

How do trade and economic growth impact environmental degradation? New evidence and policy implications from the ARDL approach

BA Asiedu, BA Gyamfi, E Oteng - Environmental Science and Pollution …, 2021 - Springer
Due to various environmental degradation and natural resource depletion around the world,
researchers' and policymakers' attention has turned to what causes environmental …

At the metal–metabolite interface in Aspergillus fumigatus: towards untangling the intersecting roles of zinc and gliotoxin

AM Traynor, RA Owens, CM Coughlin… - …, 2021 - microbiologyresearch.org
Cryptic links between apparently unrelated metabolic systems represent potential new drug
targets in fungi. Evidence of such a link between zinc and gliotoxin (GT) biosynthesis in …

Natural roles of nonribosomal peptide metabolites in fungi

S Oide, BG Turgeon - Mycoscience, 2020 - jstage.jst.go.jp
abstract Over 90 years have passed since Alexander Fleming's discovery of penicillin, the
first recognized, naturally occurring antibiotic. Penicillin is a representative of a group of …

Novel intermicrobial molecular interaction: Pseudomonas aeruginosa Quinolone Signal (PQS) modulates Aspergillus fumigatus response to iron

H Nazik, G Sass, SR Ansari, R Ertekin… - …, 2020 - microbiologyresearch.org
Pseudomonas aeruginosa (Pa) and Aspergillus fumigatus (Af), the commonest bacterium
and fungus in compromised host airways, compete for iron (Fe). The Pseudomonas …

[HTML][HTML] Anticipatory stress responses and immune evasion in fungal pathogens

A Pradhan, Q Ma, LJ de Assis, I Leaves… - Trends in …, 2021 - cell.com
In certain niches, microbes encounter environmental challenges that are temporally linked.
In such cases, microbial fitness is enhanced by the evolution of anticipatory responses …

[HTML][HTML] Distinct transcriptional responses to fludioxonil in Aspergillus fumigatus and its ΔtcsC and Δskn7 mutants reveal a crucial role for Skn7 in the cell wall …

S Schruefer, A Pschibul, SSW Wong, T Sae-Ong… - BMC genomics, 2023 - Springer
Background Aspergillus fumigatus is a major fungal pathogen that causes severe problems
due to its increasing resistance to many therapeutic agents. Fludioxonil is a compound that …

[HTML][HTML] Genome-Wide Association for Itraconazole Sensitivity in Non-resistant Clinical Isolates of Aspergillus fumigatus

S Zhao, W Ge, A Watanabe, JR Fortwendel… - Frontiers in fungal …, 2021 - frontiersin.org
Aspergillus fumigatus is a potentially lethal opportunistic pathogen that infects over~
200,000 people and causes~ 100,000 deaths per year globally. Treating A. fumigatus …