Hypertension is regarded as the most prominent risk factor for cardiovascular diseases,
which have become a primary cause of death, and recent research has demonstrated that …

The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received
special attention because of its function in the development and progression of …

Hypertension is a global health problem, with> 1.3 billion individuals with high blood
pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension …

CC motif ligand 2 (CCL2), also known as monocytic chemotactic protein 1 (MCP-1), is an
integral chemotactic factor which recruits macrophages for the immune response. Together …

Aging is characterized by alterations in neuro-cardiovascular regulatory mechanisms,
leading to impaired physiological variability patterns. Repeated evidence has shown that …

CXCR1 and CXCR2 chemokine receptors, mainly activated by interleukin 8 (IL-8 or CXCL8),
are expressed in a variety of cells including, leukocytes, fibroblasts, endothelial cells, and …

Low-grade inflammatory processes and related oxidative stress may have a key role in the
pathogenesis of hypertension and hypertension-mediated organ damage. Innate immune …

Circulating proteomic signatures of age are closely associated with aging and age-related
diseases; however, the utility of changes in secreted proteins in identifying therapeutic …

Background: Cardiac remodeling in heart failure involves macrophage-mediated immune
responses. Recent studies have shown that a PRR (pattern recognition receptor) called …

BACKGROUND: Inflammation plays a critical role in the development of hypertension and
vascular remodeling. Resolvin E1 (RvE1), as one of the specialized proresolving lipid …