First-in-human, randomized, double-blind clinical trial of differentially adjuvanted PAMVAC, a vaccine candidate to prevent pregnancy-associated malaria

B Mordmüller, M Sulyok, D Egger-Adam… - Clinical Infectious …, 2019 - academic.oup.com
Background Malaria in pregnancy has major impacts on mother and child health. To
complement existing interventions, such as intermittent preventive treatment and use of …

The case for exploiting cross-species epitopes in malaria vaccine design

CJ Mitran, SK Yanow - Frontiers in Immunology, 2020 - frontiersin.org
The infection dynamics between different species of Plasmodium that infect the same human
host can both suppress and exacerbate disease. This could arise from inter-parasite …

Progress and new horizons toward a VAR2CSA-based placental malaria vaccine

JYA Doritchamou, J Suurbaar… - Expert Review of …, 2021 - Taylor & Francis
Introduction: Several malaria vaccines are under various phases of development with some
promising results. In placental malaria (PM) a deliberately anti-disease approach is …

Sickle-trait hemoglobin reduces adhesion to both CD36 and EPCR by Plasmodium falciparum-infected erythrocytes

JEV Petersen, JW Saelens, E Freedman… - PLoS …, 2021 - journals.plos.org
Sickle-trait hemoglobin protects against severe Plasmodium falciparum malaria. Severe
malaria is governed in part by the expression of the Plasmodium falciparum Erythrocyte …

Functional antibodies against placental malaria parasites are variant dependent and differ by geographic region

J Doritchamou, A Teo, R Morrison, G Arora… - Infection and …, 2019 - Am Soc Microbiol
During pregnancy, Plasmodium falciparum-infected erythrocytes (IE) accumulate in the
intervillous spaces of the placenta by binding to chondroitin sulfate A (CSA) and elicit …

How to Accelerate Early Stage of Malaria Vaccine Development by Optimizing Functional Assays

K Miura - Vaccines, 2024 - mdpi.com
While two Plasmodium falciparum circumsporozoite protein-based pre-erythrocytic vaccines
(PEV), RTS, S and R21, have been approved by the WHO, no blood-stage vaccine (BSV) or …

Survenue du paludisme pendant la grossesse et retard de croissance intra-utérin en Afrique

MMK Accrombessi - 2018 - theses.hal.science
En Afrique sub-Saharienne, les mesures préventives contre le paludisme pendant la
grossesse ne sont mises en place qu'à partir du 2ème trimestre de la grossesse, laissant les …

Investigation of the immunological cross-reactivity between Plasmodium vivax Duffy Binding Protein and Plasmodium falciparum VAR2CSA for vaccine development

CJ Mitran - 2021 - era.library.ualberta.ca
Worldwide, an estimated 30 million pregnancies are at risk of malaria infection each year. In
pregnancy, Plasmodium falciparum parasites express a protein called VAR2CSA that …

Dynamique des infections submicroscopiques par Plasmodium falciparum pendant la grossesse au Bénin: déterminants et impact des stratégies de lutte

C Hounkonnou - 2020 - theses.hal.science
Chaque année, environ 11 millions de femmes sont exposées au paludisme gestationnel
(PG) en Afrique sub-Saharienne, avec pour principales conséquences l'anémie maternelle …

Immunoepidemiology of Plasmodium falciparum malaria

AK Bei, S Parikh - Immunoepidemiology, 2019 - Springer
Immunoepidemiology studies of malaria have historically been performed to try to identify
and understand the key targets and mechanisms of protective immunity, in order to …