Sepsis is described as a life-threatening organ dysfunction and a heterogeneous syndrome
that is a leading cause of morbidity and mortality in intensive care settings. Severe sepsis …

Sepsis involves an immunological systemic response to a microbial pathogenic insult,
leading to a cascade of interconnected biochemical, cellular, and organ–organ interaction …

Intestinal barriers play a crucial role in human physiology, both in homeostatic and
pathological conditions. Disruption of the intestinal barrier is a significant factor in the …

Our limited understanding of the pathophysiological mechanisms that operate during sepsis
is an obstacle to rational treatment and clinical trial design. There is a critical lack of data …

Sepsis is a systemic inflammatory response syndrome, and severe cases often present with
inadequate organ perfusion and multiple organ failure. The interplay of inflammation and …

Sepsis induces intense, dynamic and heterogeneous host response modulations. Despite
improvement of patient management, the risk of mortality and healthcare-associated …

Background Computational simulation of biological processes can be a valuable tool for
accelerating biomedical research, but usually requires extensive domain knowledge and …

Background Sepsis is a major contributor to global morbidity and mortality, affecting millions
each year. Notwithstanding the decline in sepsis incidence and mortality over decades …

Background The immune response of critically ill patients, such as those with sepsis, severe
trauma, or major surgery, is heterogeneous and dynamic, but its characterization and impact …

Sepsis is characterized by a dysfunctional host response to infection culminating in life-
threatening organ failure that requires complex patient management and rapid intervention …