Lipids are crucial components of cellular function owing to their role in membrane formation,
intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid …

Ceramide is a bioactive sphingolipid involved in numerous cellular processes. In addition to
being the precursor of complex sphingolipids, ceramides can act as second messengers …

Haploinsufficiency of GRN causes frontotemporal dementia (FTD). The GRN locus produces
progranulin (PGRN), which is cleaved to lysosomal granulin polypeptides. The function of …

Specific lipid species play central roles in cell biology. Their presence or enrichment in
individual membranes can control properties or direct protein localization and/or activity …

Psychiatric disorders affect 970 million people worldwide, representing a significant source
of disability. Although the underlying neurobiological traits for these disorders are not fully …

Sphingolipids play an important role in the development of diabetes, both type 1 and type 2
diabetes, as well as in the development of both micro-and macro-vascular complications …

Sphingolipids (SLs) are one of the three major lipid classes in all eukaryotic cells. They
function as structural molecules of membranes and can also act as highly active signaling …

Sphingolipids not only exert structural roles in cellular membranes, but also act as signaling
molecules in various physiological and pathological processes. A myriad of studies have …

Metabolic pathways are complex and intertwined. Deficiencies in one or more enzymes in a
given pathway are directly linked with genetic diseases, most of them having devastating …

Altered lipid metabolism is one of the hallmarks of cancer. Cellular proliferation and de novo
synthesis of lipids are related to cancer progression. In this study, we evaluated the lipidomic …