Antinociception induced by artemisinin nanocapsule in a model of postoperative pain via spinal TLR4 inhibition
LMS Elisei, TR Moraes, IH Malta, I Charlie-Silva… - …, 2020 - Springer
Artemisinin (ART) was initially described for the control of inflammation and pain. However,
the mechanisms involved with its antinociceptive effect are still poorly understood. Thus, this …
the mechanisms involved with its antinociceptive effect are still poorly understood. Thus, this …
Role of elevated thrombospondin-1 in kainic acid-induced status epilepticus
Y Zhang, M Zhang, W Zhu, X Pan, Q Wang, X Gao… - Neuroscience …, 2020 - Springer
Previous studies have suggested that thrombospondin-1 (TSP-1) regulates the transforming
growth factor beta 1 (TGF-β1)/phosphorylated Smad2/3 (pSmad2/3) pathway. Moreover …
growth factor beta 1 (TGF-β1)/phosphorylated Smad2/3 (pSmad2/3) pathway. Moreover …
The LFA-1 antagonist BIRT377 reverses neuropathic pain in prenatal alcohol-exposed female rats via actions on peripheral and central neuroimmune function in …
Previous reports show that moderate prenatal alcohol exposure (PAE) poses a risk factor for
developing neuropathic pain following adult-onset peripheral nerve injury in male rats …
developing neuropathic pain following adult-onset peripheral nerve injury in male rats …
Characterization of pain-related behaviors and gene expression profiling of peripheral sensory ganglia in a mouse model of acute ankle sprain
Y Pan, Q Hu, Y Yang, H Nie, C Yin, H Wei… - Frontiers in Behavioral …, 2023 - frontiersin.org
Introduction Lateral ankle sprain (LAS) is a very common type of joint injury. It occurred with
high incidence among general population and especially among individuals participating …
high incidence among general population and especially among individuals participating …
Spinal HMGB1 participates in the early stages of paclitaxel-induced neuropathic pain via microglial TLR4 and RAGE activation
TR Moraes, FP Veras, AR Barchuk… - Frontiers in …, 2024 - frontiersin.org
Introduction Chemotherapy-induced neuropathic pain (CINP) is one of the main adverse
effects of chemotherapy treatment. At the spinal level, CINP modulation involves glial cells …
effects of chemotherapy treatment. At the spinal level, CINP modulation involves glial cells …
Prenatal alcohol exposure is a risk factor for adult neuropathic pain via aberrant neuroimmune function
JJ Sanchez, S Noor, S Davies, D Savage… - Journal of …, 2017 - Springer
Background Clinical studies show that prenatal alcohol exposure (PAE) results in effects that
persist into adulthood. Experimental animal models of moderate PAE demonstrate that …
persist into adulthood. Experimental animal models of moderate PAE demonstrate that …
Contribution of spinal cord glial cells to L. amazonensis experimental infection-induced pain in BALB/c mice
Background The cellular and molecular pathophysiological mecha\nisms of pain processing
in neglected parasitic infections such as leishmaniasis remain unknown. The present study …
in neglected parasitic infections such as leishmaniasis remain unknown. The present study …
Environmental experiences shape sexually dimorphic neuronal circuits and behaviour
S Peedikayil‐Kurien, H Setty… - The FEBS …, 2024 - Wiley Online Library
Dimorphic traits, shaped by both natural and sexual selection, ensure optimal fitness and
survival of the organism. This includes neuronal circuits that are largely affected by different …
survival of the organism. This includes neuronal circuits that are largely affected by different …
Astrocytic calcium dynamics along the pain pathway
J Cho, Y Huh - Frontiers in cellular neuroscience, 2020 - frontiersin.org
Astrocytes, once thought to be passive cells merely filling the space between neurons in the
nervous system, are receiving attention as active modulators of the brain and spinal cord …
nervous system, are receiving attention as active modulators of the brain and spinal cord …
Choice of intrathecal drug in the treatment of neuropathic pain–new research and opinion
TR Deer, M Malinowski, V Varshney… - Expert review of clinical …, 2019 - Taylor & Francis
Introduction: The choice of the proper intrathecal drug to treat neuropathic pain has been
subject to much debate in recent years. Areas Covered: Currently, the United States Food …
subject to much debate in recent years. Areas Covered: Currently, the United States Food …