Chemotherapy-induced neuropathic pain (CINP) in both sexes compromises many current
chemotherapeutics and lacks an FDA-approved therapy. We recently identified the …

Background Paclitaxel is a widely used and potent chemotherapeutic agent for the treatment
of cancer. However, patients receiving paclitaxel often develop an acute pain syndrome for …

HIV-associated neuropathic pain (HNP) is a common complication for AIDS patients. The
pathological mechanism governing HNP has not been elucidated, and HNP has no effective …

Microglial activation with the production of pro-inflammatory mediators such as IL-6, TNF-α,
and IL-1β, is a major driver of neuropathic pain (NP) following peripheral nerve injury. We …

Background Voltage-gated sodium channel Nav1. 7 has been validated as a perspective
target for selective inhibitors with analgesic and anti-itch activity. The objective of this study …

Withdrawal from systemic opioids can induce long-term potentiation (LTP) at spinal C-fibre
synapses (“opioid-withdrawal-LTP”). This is considered to be a cellular mechanism …

The management of neuropathic pain, defined as pain as a result of a lesion or disease in
the somatosensory nervous system, continues to be researched and explored. As …

Background Sex differences in pain sensitivity have been well documented, such that
women often report greater sensitivity than men. However, clinical reports highlighting sex …

Background Neuropathic pain following peripheral nerve injury (PNI) is linked to
neuroinflammation in the spinal cord marked by astrocyte activation and upregulation of …

Minimizing central nervous system (CNS) injury from preterm birth depends upon
identification of the critical pathways that underlie essential neurodevelopmental and CNS …