Targeting FMN, TPP, SAM-I, and glmS Riboswitches with Chimeric Antisense Oligonucleotides for Completely Rational Antibacterial Drug Development

N Pavlova, M Traykovska, R Penchovsky - Antibiotics, 2023 - mdpi.com
Antimicrobial drug resistance has emerged as a significant challenge in contemporary
medicine due to the proliferation of numerous bacterial strains resistant to all existing …

Antimicrobial resistance of Pseudomonas aeruginosa: navigating clinical impacts, current resistance trends, and innovations in breaking therapies

A Elfadadny, RF Ragab, M AlHarbi, F Badshah… - Frontiers in …, 2024 - frontiersin.org
Pseudomonas aeruginosa, a Gram-negative bacterium, is recognized for its adaptability and
opportunistic nature. It poses a substantial challenge in clinical settings due to its …

Evaluation of the BD Phoenix carbapenemase-producing organism panels for the detection of Carbapenemase Producers in Escherichia coli, Klebsiella pneumoniae …

YP Correa-León, JM Pérez-Hernández… - Diagnostics, 2023 - mdpi.com
The classification of carbapenemases can help guide therapy. The present study evaluated
the performance of the CPO detection test, included in the BD Phoenix™ NMIC-501 panel …

Rapid detection of mexX in Pseudomonas aeruginosa based on CRISPR-Cas13a coupled with recombinase polymerase amplification

XX Zhu, YS Wang, SJ Li, RQ Peng, X Wen… - Frontiers in …, 2024 - frontiersin.org
The principal pathogen responsible for chronic urinary tract infections, immunocompromised
hosts, and cystic fibrosis patients is Pseudomonas aeruginosa, which is difficult to eradicate …

Evaluation of fortimicin antibiotic combinations against MDR Pseudomonas aeruginosa and resistome analysis of a whole genome sequenced pan-drug resistant …

NA Kamel, ST Tohamy, MY Alshahrani… - BMC microbiology, 2024 - Springer
Abstract Background Multidrug-resistant (MDR) P. aeruginosa is a rising public health
concern, challenging the treatment of such a ubiquitous pathogen with monotherapeutic anti …

Methyl gallate attenuates virulence and decreases antibiotic resistance in extensively drug-resistant Pseudomonas aeruginosa

O Flores-Maldonado, CI Lezcano-Domínguez… - Microbial …, 2024 - Elsevier
Pseudomonas aeruginosa infections have become a serious threat to public health due to
the increasing emergence of extensively antibiotic-resistant strains and high mortality rates …

[HTML][HTML] Comparison of Different Methods for Assaying the In Vitro Activity of Cefiderocol against Carbapenem-Resistant Pseudomonas aeruginosa Strains: Influence …

C García-Rivera, A Sánchez-Bautista, M Parra-Grande… - Antibiotics, 2024 - mdpi.com
Carbapenem-resistant Pseudomonas aeruginosa infections represent a critical public health
concern, highlighting the need for the development of effective antibiotics. Cefiderocol …

Modulating the antibacterial effect of the existing antibiotics along with repurposing drug metformin

S Hossain, RH Rafi, FA Ripa, MRI Khan… - Archives of …, 2024 - Springer
Owing to the extensive prevalence of resistant bacteria to numerous antibiotic classes,
antimicrobial resistance (AMR) poses a well-known hazard to world health. As an alternate …

Evaluating the Expression of Efflux Pumps in Pseudomonas aeruginosa in Exposure to Sodium Dodecyl Sulfate, Didecyldimethylammonium Chloride, and …

K Alsamhary - Microbial Drug Resistance, 2024 - liebertpub.com
Emerging resistance of Gram-negative bacteria, including Pseudomonas aeruginosa, to
commonly used detergents and disinfectant is encountering us with hazard. Inappropriate …

Resistome Signature and Antibiotic Resistance Mechanisms in Rhizospheric Soil Bacteriomes of Mecca Region, Saudi Arabia: Insights into Impact on Human Health

RS Jalal, HS Sonbol - Life, 2024 - mdpi.com
The objective of this investigation is to ascertain the distinctive profile of the rhizospheric soil
resistome within the Mecca region, while also evaluating the potential risks associated with …