[HTML][HTML] Doença de Alzheimer: hipóteses etiológicas e perspectivas de tratamento
With the increase in life expectancy registered in the past few decades, the prevalence of
various medical conditions related to aging has been observed, such as dementia and …
various medical conditions related to aging has been observed, such as dementia and …
Acetylcholinesterase involvement in apoptosis
XJ Zhang, DS Greenberg - Frontiers in molecular neuroscience, 2012 - frontiersin.org
To date, more than 40 different types of cells from primary cultures or cell lines have shown
AChE expression during apoptosis and after the induction apoptosis by different stimuli. It …
AChE expression during apoptosis and after the induction apoptosis by different stimuli. It …
Quercetin exhibits α7nAChR/Nrf2/HO-1-mediated neuroprotection against STZ-induced mitochondrial toxicity and cognitive impairments in experimental rodents
NK Singh, D Garabadu - Neurotoxicity Research, 2021 - Springer
The objective of the present study was to investigate the α7nAChR-mediated Nrf2-
dependant protective activity against streptozotocin (STZ)-induced brain mitochondrial …
dependant protective activity against streptozotocin (STZ)-induced brain mitochondrial …
Hypoxia-Induced Neuroinflammation in Alzheimer's Disease: Potential Neuroprotective Effects of Centella asiatica
Alzheimer's disease (AD) is a neurodegenerative disorder that is characterised by the
presence of extracellular beta-amyloid fibrillary plaques and intraneuronal neurofibrillary tau …
presence of extracellular beta-amyloid fibrillary plaques and intraneuronal neurofibrillary tau …
Near-infrared fluorescence probe for evaluating acetylcholinesterase activity in PC12 cells and in situ tracing AChE distribution in zebrafish
J Ma, T Si, C Yan, Y Li, Q Li, X Lu, Y Guo - ACS sensors, 2019 - ACS Publications
Acetylcholinesterase (AChE) plays crucial roles in numerous physiological processes such
as cell differentiation, cell apoptosis, and nerve tissue developments. Hence, it is highly …
as cell differentiation, cell apoptosis, and nerve tissue developments. Hence, it is highly …
Quercetin ameliorates hypobaric hypoxia-induced memory impairment through mitochondrial and neuron function adaptation via the PGC-1α pathway
P Liu, D Zou, L Yi, M Chen, Y Gao… - Restorative …, 2015 - content.iospress.com
Purpose: Acute hypobaric hypoxia (HH) causes persistent cognitive impairment, affecting
memory function specifically. Mitochondrial dysfunction and synaptic morphological change …
memory function specifically. Mitochondrial dysfunction and synaptic morphological change …
Withania somnifera root extract ameliorates hypobaric hypoxia induced memory impairment in rats
I Baitharu, V Jain, SN Deep, KB Hota, SK Hota… - Journal of …, 2013 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Withania somnifera (WS) root extract has been
used traditionally in ayurvedic system of medicine as a memory enhancer and anti-stress …
used traditionally in ayurvedic system of medicine as a memory enhancer and anti-stress …
Enriched environment prevents hypobaric hypoxia induced memory impairment and neurodegeneration: role of BDNF/PI3K/GSK3β pathway coupled with CREB …
V Jain, I Baitharu, D Prasad, G Ilavazhagan - PloS one, 2013 - journals.plos.org
Adverse environmental conditions such as hypobaric hypoxia (HH) cause memory
impairment by affecting cellular machinery leading to neurodegeneration. Providing …
impairment by affecting cellular machinery leading to neurodegeneration. Providing …
Exendin-4 attenuates brain mitochondrial toxicity through PI3K/Akt-dependent pathway in amyloid beta (1–42)-induced cognitive deficit rats
D Garabadu, J Verma - Neurochemistry International, 2019 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
memory loss, disorientation and gradual deterioration of intellectual ability. In the …
memory loss, disorientation and gradual deterioration of intellectual ability. In the …
Chronic administration of troxerutin protects mouse brain against D-galactose-induced impairment of cholinergic system
Previous evidence showed that administration of d-galactose (d-gal) increased ROS
production and resulted in impairment of cholinergic system. Troxerutin, a natural …
production and resulted in impairment of cholinergic system. Troxerutin, a natural …