Functional supramolecular systems: Design and applications

IS Antipin, MV Alfimov, VV Arslanov… - Russian Chemical …, 2021 - iopscience.iop.org
The interest in functional supramolecular systems for the design of innovative materials and
technologies, able to fundamentally change the world, is growing at a high pace. The huge …

Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives

RK Singh, S Kumar, DN Prasad… - European journal of …, 2018 - Elsevier
Cancer is considered as one of the most serious health problems today. The discovery of
nitrogen mustard as an alkylating agent in 1942, opened a new era in the cancer …

Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands

WDJ Tremlett, DM Goodman, TR Steel, S Kumar… - Coordination Chemistry …, 2021 - Elsevier
The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …

[HTML][HTML] Recent developments in the synthesis and biological activity of acridine/acridone analogues

M Gensicka-Kowalewska, G Cholewiński… - RSC …, 2017 - pubs.rsc.org
Many people in the world struggle with cancer or bacterial, parasitic, viral, Alzheimer's and
other diseases. Therefore, many scientists seek new, more effective, more selective and less …

Recent advances in small organic molecules as DNA intercalating agents: Synthesis, activity, and modeling

A Rescifina, C Zagni, MG Varrica, V Pistarà… - European journal of …, 2014 - Elsevier
The interaction of small molecules with DNA plays an essential role in many biological
processes. As DNA is often the target for majority of anticancer and antibiotic drugs, study …

The search of DNA-intercalators as antitumoral drugs: what it worked and what did not work

R Martinez, L Chacon-Garcia - Current medicinal chemistry, 2005 - ingentaconnect.com
The discovery of new compounds with antitumoral activity has become one of the most
important goals in medicinal chemistry. One interesting group of chemotherapeutic agents …

Quinoline anticancer agents active on DNA and DNA-interacting proteins: From classical to emerging therapeutic targets

A Lauria, G La Monica, A Bono, A Martorana - European Journal of …, 2021 - Elsevier
Quinoline is one of the most important and versatile nitrogen heterocycles embodied in
several biologically active molecules. Within the numerous quinolines developed as …

[HTML][HTML] Recent applications of Rose Bengal catalysis in N-heterocycles: a short review

A Srivastava, PK Singh, A Ali, PP Singh, V Srivastava - RSC advances, 2020 - pubs.rsc.org
The visible light harnessing ability of Rose Bengal, an organic dye, has been extensively
employed in organic chemistry over the last few years. In visible light mediated reactions …

PhI(OAc)2-Mediated Synthesis of 6-(Trifluoromethyl)phenanthridines by Oxidative Cyclization of 2-Isocyanobiphenyls with CF3SiMe3 under Metal-Free Conditions

Q Wang, X Dong, T Xiao, L Zhou - Organic letters, 2013 - ACS Publications
A mild and efficient method for the synthesis of 6-(trifluoromethyl) phenanthridines through
oxidative cyclization of 2-isocyanobiphenyls with CF3SiMe3 under metal-free conditions …

On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs

CC Wu, YC Li, YR Wang, TK Li… - Nucleic acids research, 2013 - academic.oup.com
Type II topoisomerases (Top2s) alter DNA topology via the formation of an enzyme–DNA
adduct termed cleavage complex, which harbors a transient double-strand break in one …