The macrophage, a versatile cell type prominently involved in host defense and immunity,
assumes a distinct state of alternative activation in the context of polarized type 2 immune …

In all animal cells, phospholipids are asymmetrically distributed between the outer and inner
leaflets of the plasma membrane. This asymmetrical phospholipid distribution is disrupted in …

Clearance of apoptotic cells is the final stage of programmed cell death. Uncleared corpses
can become secondarily necrotic, promoting inflammation and autoimmunity. Remarkably …

Under normal physiological conditions, tissue remodeling in response to injury leads to
tissue regeneration without permanent damage. However, if homeostasis between synthesis …

Progressive accrual of senescent cells in aging and chronic diseases is associated with
detrimental effects in tissue homeostasis. We found that senescent fibroblasts and epithelia …

As the body continues to grow and age, it becomes essential to maintain a balance between
living and dying cells. Macrophages and dendritic cells play a central role in discriminating …

Asymmetrical distribution of phospholipids between the inner and outer plasma membrane
leaflets is disrupted in various biological processes. We recently identified TMEM16F, an …

Osteoclasts (OCLs) are hematopoietic cells whose physiological function is to degrade
bone. OCLs are key players in the processes that determine and maintain the mass, shape …

Macrophage cell fusion and multinucleation are fundamental processes in the formation of
multinucleated giant cells (MGCs) in chronic inflammatory disease and osteoclasts in the …

Monocytes and macrophages are innate immune cells with diverse functions ranging from
phagocytosis of microorganisms to forming a bridge with the adaptive immune system. A …