ABSTRACT mφ are heterogeneous in their functions, and although it is clear that
inflammatory mφ contribute to inflammation in IBDs, multiple lines of evidence suggest that …

Cell–cell fusion is an evolutionarily conserved process that leads to the formation of
multinucleated myofibers, syncytiotrophoblasts and osteoclasts, allowing their respective …

Excessive bone resorption by osteoclasts (OCs) can result in serious clinical outcomes,
including bone loss that may weaken skeletal or periodontal strength. Proper bone …

The death fold domain-containing protein PIDD1 has recently attracted renewed attention as
a regulator of the orphan cell death-related protease, Caspase-2. Caspase-2 can activate …

Osteoclasts, responsible for bone resorption, are multinucleated cells formed by cell-cell
fusion of mononuclear pre-osteoclasts. Although osteoclast fusion is a pivotal step for …

Due to its excellent bone-like mechanical properties and non-toxicity, magnesium (Mg) and
its alloys have attracted great interest as biomaterials for orthopaedic applications. However …

Over a century ago, the seminal work of Ramón y Cajal revealed that the nervous system is
made of individual units, the neurons, which are related to each other by contiguity rather …

The biological phenomenon of cell fusion plays a crucial role in several physiological
processes, including wound healing and tissue regeneration. Here, it is assumed that bone …

The spondyloarthropathies (SpA) share characteristic clinical and histopathologic
manifestations, and have long been thought to share genetic causes, including HLA-B27 …

Implantation of biomaterials in vascularized tissues elicits the sequential engagement of
molecular and cellular elements that constitute the foreign body response. Initial events …