Methamphetamine: effects on the brain, gut and immune system

MD Prakash, K Tangalakis, J Antonipillai… - Pharmacological …, 2017 - Elsevier
Methamphetamine (METH) is a powerful central nervous system stimulant which elevates
mood, alertness, energy levels and concentration in the short-term. However, chronic use …

Methamphetamine dysregulation of the central nervous system and peripheral immunity

DR Miller, M Bu, A Gopinath, LR Martinez… - … of Pharmacology and …, 2021 - ASPET
Methamphetamine (METH) is a potent psychostimulant that increases extracellular
monoamines, such as dopamine and norepinephrine, and affects multiple tissue and cell …

Methamphetamine induces systemic inflammation and anxiety: the role of the gut–immune–brain axis

M Davidson, M Mayer, A Habib, N Rashidi… - International journal of …, 2022 - mdpi.com
Methamphetamine (METH) is a highly addictive drug abused by millions of users worldwide,
thus becoming a global health concern with limited management options. The inefficiency of …

Escalating dose-multiple binge methamphetamine treatment elicits neurotoxicity, altering gut microbiota and fecal metabolites in mice

LJ Chen, X Zhi, KK Zhang, LB Wang, JH Li… - Food and Chemical …, 2021 - Elsevier
Methamphetamine (METH) is an addictive and illegal psychostimulant drug that can cause
multiple organ dysfunction, especially in the central nervous system (CNS). Gut microbiota …

Methamphetamine (MA) use and MA-induced psychosis are associated with increasing aberrations in the compensatory immunoregulatory system, interleukin-1α …

R Kalayasiri, K Dadwat, S Thika… - Translational …, 2023 - nature.com
There are only a few studies reporting on the immunological profiles of methamphetamine
(MA) use, MA dependency, or MA-induced psychosis (MAP). This study measured M1 …

Drugs and bugs: the gut-brain axis and substance use disorders

S Simpson, R Mclellan, E Wellmeyer, F Matalon… - Journal of Neuroimmune …, 2022 - Springer
Substance use disorders (SUDs) represent a significant public health crisis. Worldwide,
5.4% of the global disease burden is attributed to SUDs and alcohol use, and many more …

Current understanding of methamphetamine-associated dopaminergic neurodegeneration and psychotoxic behaviors

EJ Shin, DK Dang, TV Tran, HQ Tran, JH Jeong… - Archives of Pharmacal …, 2017 - Springer
Clinical and preclinical studies have indicated that chronic methamphetamine (MA) use is
associated with extensive neurodegeneration, psychosis, and cognitive impairment …

High prevalence of co-occurring substance use in individuals with opioid use disorder

JJ Mahoney III, EL Winstanley, LR Lander, JH Berry… - Addictive …, 2021 - Elsevier
Objective Funding to address the current opioid epidemic has focused on treatment of opioid
use disorder (OUD); however, rates of other substance use disorders (SUDs) remain high …

The sigma-1 receptor as a regulator of dopamine neurotransmission: a potential therapeutic target for methamphetamine addiction

DO Sambo, JJ Lebowitz, H Khoshbouei - Pharmacology & therapeutics, 2018 - Elsevier
Methamphetamine (METH) abuse is a major public health issue around the world, yet there
are currently no effective pharmacotherapies for the treatment of METH addiction. METH is a …

Alterations to the gastrointestinal microbiome associated with methamphetamine use among young men who have sex with men

RR Cook, JA Fulcher, NH Tobin, F Li, DJ Lee… - Scientific reports, 2019 - nature.com
Methamphetamine (MA) use is a major public health problem in the United States,
especially among people living with HIV (PLWH). Many MA-induced neurotoxic effects are …