Non-viral gene delivery systems are one of the most potential alternatives to viral vectors
because of their less immunogenicity, less toxicity and easy productivity in spite of their low …

Drug and gene delivery systems based on nanoparticles, microparticles and hydrogels have
been widely studied for cancer treatment in the past decade. To achieve an efficient and …

Biodegradable polymeric nanoparticles have the potential to be safer alternatives to viruses
for gene delivery; however, their use has been limited by poor efficacy in vivo. In this work …

siRNA nanomedicines can potentially treat many human diseases, but safe and effective
delivery remains a challenge. DNA delivery polymers such as poly (β-amino ester) s …

The application of RNA interference (RNAi) for inflammatory bowel disease (IBD) therapy
has been limited by the lack of non-cytotoxic, efficient and targetable small interfering RNA …

Bacterial cellulose (BC) is an excellent renewable resource of high-purity cellulose that can
be used as original fiber forms or isolated nanocrystalline forms, known as bacterial …

Due to the potential use as transfecting agents of nucleic acids (DNA or RNA), multivalent
cationic non-viral vectors have received special attention in the last decade. Much effort has …

Introduction: The delivery of nucleic acid therapeutics through non-viral carriers face multiple
biological barriers that reduce their therapeutic efficiency. Despite great progress, there …

Poly (amidoamine) s (PAAs) are a family of synthetic polymers obtained by stepwise
polyaddition of prim‐or sec‐amines to bisacrylamides. Nearly all conceivable …

Despite the extracellular barriers for siRNA delivery have been overcome by utilizing
advanced nanoparticle delivery systems, the key intracellular barriers after internalization …