Autism Spectrum Disorder (ASD), a neurodevelopmental disorder characterized by
persistent deficits in social interaction and communication, manifests in early childhood and …

As synaptic vesicles fuse, they must continually be replaced with new docked, fusion-
competent vesicles to sustain neurotransmission. It has long been appreciated that vesicles …

Sustained neuronal activity demands a rapid resupply of synaptic vesicles to maintain
reliable synaptic transmission. Such vesicle replenishment is accelerated by submicromolar …

Pre-and postsynaptic forms of long-term potentiation (LTP) are candidate synaptic
mechanisms underlying learning and memory. At layer 5 pyramidal neurons, LTP increases …

Calcium directly controls or indirectly regulates numerous functions that are critical for
neuronal network activity. Intracellular calcium concentration is tightly regulated by …

A primary reason behind the high level of complexity we embody as multicellular organisms
is a highly complex intracellular and intercellular communication system. As a result, the …

Neurotransmitter release from presynaptic terminals is primarily regulated by rapid Ca2+
influx through membrane-resident voltage-gated Ca2+ channels (VGCCs). Moreover …

Subthreshold depolarization enhances neurotransmitter release evoked by action potentials
and plays a key role in modulating synaptic transmission by combining analog and digital …

A stunning example of synaptic diversity is the postsynaptic target cell-type-dependent
difference in synaptic efficacy in cortical networks. Here, we show that CA1 pyramidal cell …

Recent research suggests that in central mammalian synapses, active zones contain several
docking sites acting in parallel. Before release, one or several synaptic vesicles (SVs) are …