Targeting autophagy and neuroinflammation pathways with plant‐derived natural compounds as potential antidepressant agents

T Mokhtari - Phytotherapy Research, 2022 - Wiley Online Library
Major depressive disorder (MDD) is a life‐threatening disease that presents several
characteristics. The pathogenesis of depression still remains poorly understood. Moreover …

Potential anxiolytic and antidepressant-like effects of luteolin in a chronic constriction injury rat model of neuropathic pain: Role of oxidative stress, neurotrophins, and …

T Mokhtari, M Lu, AEM El-Kenawy - International Immunopharmacology, 2023 - Elsevier
This study aimed to examine the effects of luteolin (LUT) on chronic neuropathic pain (NP)-
induced mood disorders (ie, anxiety and depression) by regulating oxidative stress …

[HTML][HTML] Neutrophil-to-lymphocyte ratio as a predictive biomarker for early diagnosis of depression: A narrative review

SS Ghafori, Z Yousefi, E Bakhtiari… - Brain, Behavior, & …, 2024 - Elsevier
Depression is a mood disorder that causes persistent feelings of sadness, hopelessness,
loss of interest, and decreased energy. Early diagnosis of depression can improve its …

Resveratrol attenuates chronic social isolation stress‐induced affective disorders: Involvement of NF‐κB/NLRP3 axis

M Zarebavani, F Baghaei Naeini… - … of Biochemical and …, 2023 - Wiley Online Library
Social isolation stress (SIS) is associated with affective disorders (ie, anxiety and
depression) in adults. In a preclinical study, we aimed to investigate the effects of resveratrol …

[HTML][HTML] Curcumin ameliorates chronic Toxoplasma gondii infection-induced affective disorders through modulation of proinflammatory cytokines and oxidative stress

F Moradi, N Dashti, A Farahvash… - Iranian Journal of …, 2023 - ncbi.nlm.nih.gov
Objective (s): Long-term infection with Toxoplasma gondii is associated with affective
disorders (ie, anxiety and depression) in adults. We aimed to explore the effects of curcumin …

[HTML][HTML] Luteolin reversed anxiety and depressive-like behavior via modulation of the NF-κB/NLRP3 inflammasome axis in the hippocampus of rats subjected to sleep …

F Xiong, X Lv - Iranian Journal of Basic Medical Sciences, 2024 - ncbi.nlm.nih.gov
Objective (s): In this study, we assessed the impact of luteolin (LUT) on mood disorders
(specifically anxiety and depression) induced by sleep deprivation (SD) by regulating …