Medical case reports suggest that cannabinoids extracted from Cannabis sativa have
therapeutic effects; however, the therapeutic employment is limited due to the psychotropic …

Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent
neurodegenerative diseases, affecting millions and costing billions each year in the United …

In this review, the state of the art for compounds affecting the endocannabinoid (eCB)
system is described with a focus on the treatment of pain. Amongst directly acting CB …

Introduction Frontotemporal dementia (FTD) is a complex neurodegenerative disorder,
characterized by a wide range of pathological conditions associated with the buildup of …

Background and Purpose T‐type Ca channels (ICa) regulate neuronal excitability and
contribute to neurotransmitter release. The phytocannabinoids Δ9‐tetrahydrocannabinol …

The relationship between man and substances that have abuse potentials, and whose use
has been associated with the development or progression of substance use disorders has …

We apply the magic methyl effect to improve the potency/efficacy of GAT211, the prototypic 2-
phenylindole-based cannabinoid type-1 receptor (CB1R) agonist-positive allosteric …

BACKGROUND: Increasing attention has been attracted to the development of bifunctional
compounds to minimize the side effects of opioid analgesics. Pharmacological studies have …

The endocannabinoid system (ECS) dynamically regulates many aspects of mammalian
physiology. ECS has gained substantial interest since growing evidence suggests that it …

Cannabis plant has been used from ancient times with therapeutic purposes for treating
human pathologies, but the identification of the cellular and molecular mechanisms …