The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

Pharmaceutical cocrystals are multicomponent systems in which at least one component is
an active pharmaceutical ingredient and the others are pharmaceutically acceptable …

Originally discovered almost a century ago, cocrystals continue to gain interest in the
modern day due to their ability to modify the physical properties of solid-state materials …

Cannabidiol (CBD) has substantial therapeutic potential, but its development as an effective
drug by the pharmaceutical industry is hindered by intrinsic characteristics such as low …

Encapsulating a drug molecule into a water‐reactive metal–organic framework (MOF) leads
to amorphous drug confined within the nanoscale pores. Rapid release of drug occurs upon …

This Tutorial Review, aimed at both the novice and the seasoned solid-state chemist,
provides a succinct overview of key findings that have, over the last half century, advanced …

Highlights•Discovery of pharmaceutical cocrystals has evolved from serendipity to
design.•Contains an overview of all commercially available pharmaceutical …

Pharmaceutical cocrystals belong to a sub-class of cocrystals wherein one of the
components is a drug molecule (or an active pharmaceutical ingredient, API) and the …

As small molecule drugs become harder to develop and less cost effective for patient use,
efficient strategies for their property improvement become increasingly important to global …

Cocrystal engineering, involving the assembly of two or more components into a highly
ordered solid-state superstructure, has emerged as a popular strategy for tuning the …