Cryptococcus neoformans and Cryptococcus gattii species complexes cause
meningoencephalitis with high fatality rates and considerable morbidity, particularly in …

Cryptococcal meningitis is a leading cause of morbidity and mortality globally, especially in
people with advanced HIV disease. Cryptococcal meningitis is responsible for nearly 20% of …

Background Cryptococcal meningitis is the most common cause of meningitis in adults living
with HIV in sub-Saharan Africa. The estimates of national, regional, and global burden of …

Background High-dose rifampicin may improve outcomes of tuberculous meningitis (TBM).
Little safety or pharmacokinetic (PK) data exist on high-dose rifampicin in human …

Tuberculous meningitis (TBM) is the most lethal form of tuberculosis. The incidence and
mortality of TBM is unknown due to diagnostic challenges and limited disaggregated …

Fungi are eukaryotic microorganisms found in nature, which can invade the human body
and cause tissue damage, inflammatory reactions, organ dysfunctions, and diseases. These …

Cryptococcal meningitis, mainly caused by Cryptococcus neoformans/gattii species
complexes, is a lethal infection in both immunosuppressive and immunocompetent …

Background Cryptococcal meningitis is a common cause of AIDS-related mortality. Although
symptom recurrence after initial treatment is common, the etiology is often difficult to …

Background Meningitis causes significant mortality in sub-Saharan Africa and limited
diagnostics exist. We evaluated the utility of the BioFire® FilmArray® Meningitis/Encephalitis …

Background Tuberculous meningitis (TBM) has a high fatality rate, with inadequate
diagnostic tests being a major contributor. The rollout of Xpert MTB/Rif and Xpert MTB/RIF …