Connexins constitute a large family of trans-membrane proteins that allow intercellular
communication and the transfer of ions and small signaling molecules between cells …

The field of hemichannels is closely related to the purinergic signaling and both areas have
been growing in parallel. Hemichannels open in response to a wide range of stressful …

Abstract “Hemichannels” are defined as the halves of gap junction channels (also termed
connexons) that are contributed by one cell;“hemichannels” are considered to be functional …

In recent years our understanding of connexins has advanced from viewing them simply as
proteins with a surprisingly short lifespan that form gap junction channels. Connexins are …

Evidence is accumulating that some forms of cell death, like apoptosis, are not only
governed by the complex interplay between extracellular and intracellular signals but are …

In the brain, astrocytes represent the cellular population that expresses the highest amount
of connexins (Cxs). This family of membrane proteins is the molecular constituent of gap …

In myelinating Schwann cells, connection between myelin layers is mediated by gap
junction channels (GJCs) formed by docked connexin 32 (Cx32) hemichannels (HCs) …

ATP is a paracrine regulator of critical airway epithelial cell functions, but the mechanism of
its release is poorly understood. Pannexin (Panx) proteins, related to invertebrate innexins …

BACKGROUND Connexins comprise a family of∼ 20 proteins that form intercellular
membrane channels (gap junction channels) providing a direct route for metabolites and …

Chronic neuropathic pain is a frequent consequence of spinal cord injury (SCI). Yet despite
recent advances, upstream releasing mechanisms and effective therapeutic options remain …